FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313292225> ?p ?o ?g. }

• W4313292225 abstract "Abstract PIN proteins establish the auxin concentration gradient, which coordinates plant growth. PIN1-4 and 7 localized at the plasma membrane (PM) and facilitate polar auxin transport while the endoplasmic reticulum (ER) localized PIN5 and PIN8 maintain the intracellular auxin homeostasis. Although an antagonistic activity of PIN5 and PIN8 proteins in regulating the intracellular auxin homeostasis and other developmental events have been reported, how the two proteins which localize at the same intracellular compartment antagonize each other remains unclear. Combining immunolocalization, pH-dependent fluorescent quenching, and topology prediction programs, we mapped the membrane topology of PIN5 and PIN8 in Arabidopsis thaliana root cells. Our results indicate that, except for the similarities in the orientation of the N-terminus, PIN5 and PIN8 have an opposite orientation of the central hydrophilic loop and the C-terminus, as well as an unequal number of transmembrane domains (TMDs). PIN8 has ten TMDs with groups of five alpha-helices separated by the central hydrophilic loop (HL) residing in the ER lumen, and its N- and C-terminals are positioned in the cytoplasm. However, topology of PIN5 comprises nine TMDs. Its N-terminal end and the central HL face the cytoplasm while its C-terminus resides in the ER lumen. Overall, the divergent membrane topology of PIN5 and PIN8 provides a possible explanation for the mutually opposing activity of these intracellular auxin homeostasis regulators." @default.
• W4313292225 created "2023-01-06" @default.
• W4313292225 creator A5019284781 @default.
• W4313292225 creator A5024004088 @default.
• W4313292225 creator A5047610374 @default.
• W4313292225 creator A5067859477 @default.
• W4313292225 creator A5071681621 @default.
• W4313292225 date "2022-12-27" @default.
• W4313292225 modified "2023-10-09" @default.
• W4313292225 title "The intracellular auxin homeostasis regulators PIN5 and PIN8 have a divergent membrane topology in<i>Arabidopsis thaliana</i>root cells" @default.
• W4313292225 cites W1964241324 @default.
• W4313292225 cites W1974123346 @default.
• W4313292225 cites W1978372269 @default.
• W4313292225 cites W1978385709 @default.
• W4313292225 cites W1998484135 @default.
• W4313292225 cites W2002217310 @default.
• W4313292225 cites W2025565421 @default.
• W4313292225 cites W2029069158 @default.
• W4313292225 cites W2031213514 @default.
• W4313292225 cites W2032169043 @default.
• W4313292225 cites W2038594751 @default.
• W4313292225 cites W2053412229 @default.
• W4313292225 cites W2098115340 @default.
• W4313292225 cites W2108809220 @default.
• W4313292225 cites W2109262751 @default.
• W4313292225 cites W2112965894 @default.
• W4313292225 cites W2115102727 @default.
• W4313292225 cites W2137231405 @default.
• W4313292225 cites W2138156749 @default.
• W4313292225 cites W2139941877 @default.
• W4313292225 cites W2160038364 @default.
• W4313292225 cites W2162329831 @default.
• W4313292225 cites W2436075400 @default.
• W4313292225 cites W2466710937 @default.
• W4313292225 cites W2474289942 @default.
• W4313292225 cites W2520524418 @default.
• W4313292225 cites W2739999456 @default.
• W4313292225 cites W2809102402 @default.
• W4313292225 cites W2810440784 @default.
• W4313292225 cites W2935400920 @default.
• W4313292225 cites W2961309803 @default.
• W4313292225 cites W3082132849 @default.
• W4313292225 cites W3177828909 @default.
• W4313292225 cites W3211795435 @default.
• W4313292225 cites W4213331717 @default.
• W4313292225 cites W4283751730 @default.
• W4313292225 doi "https://doi.org/10.1101/2022.12.27.522031" @default.
• W4313292225 hasPublicationYear "2022" @default.
• W4313292225 type Work @default.
• W4313292225 citedByCount "0" @default.
• W4313292225 crossrefType "posted-content" @default.
• W4313292225 hasAuthorship W4313292225A5019284781 @default.
• W4313292225 hasAuthorship W4313292225A5024004088 @default.
• W4313292225 hasAuthorship W4313292225A5047610374 @default.
• W4313292225 hasAuthorship W4313292225A5067859477 @default.
• W4313292225 hasAuthorship W4313292225A5071681621 @default.
• W4313292225 hasBestOaLocation W43132922251 @default.
• W4313292225 hasConcept C104317684 @default.
• W4313292225 hasConcept C114614502 @default.
• W4313292225 hasConcept C118892022 @default.
• W4313292225 hasConcept C143065580 @default.
• W4313292225 hasConcept C158617107 @default.
• W4313292225 hasConcept C181199279 @default.
• W4313292225 hasConcept C184720557 @default.
• W4313292225 hasConcept C190062978 @default.
• W4313292225 hasConcept C207778908 @default.
• W4313292225 hasConcept C2775988993 @default.
• W4313292225 hasConcept C2776879804 @default.
• W4313292225 hasConcept C2779491563 @default.
• W4313292225 hasConcept C33923547 @default.
• W4313292225 hasConcept C41625074 @default.
• W4313292225 hasConcept C515207424 @default.
• W4313292225 hasConcept C534586 @default.
• W4313292225 hasConcept C55493867 @default.
• W4313292225 hasConcept C57711820 @default.
• W4313292225 hasConcept C79879829 @default.
• W4313292225 hasConcept C86803240 @default.
• W4313292225 hasConcept C95444343 @default.
• W4313292225 hasConcept C98539663 @default.
• W4313292225 hasConceptScore W4313292225C104317684 @default.
• W4313292225 hasConceptScore W4313292225C114614502 @default.
• W4313292225 hasConceptScore W4313292225C118892022 @default.
• W4313292225 hasConceptScore W4313292225C143065580 @default.
• W4313292225 hasConceptScore W4313292225C158617107 @default.
• W4313292225 hasConceptScore W4313292225C181199279 @default.
• W4313292225 hasConceptScore W4313292225C184720557 @default.
• W4313292225 hasConceptScore W4313292225C190062978 @default.
• W4313292225 hasConceptScore W4313292225C207778908 @default.
• W4313292225 hasConceptScore W4313292225C2775988993 @default.
• W4313292225 hasConceptScore W4313292225C2776879804 @default.
• W4313292225 hasConceptScore W4313292225C2779491563 @default.
• W4313292225 hasConceptScore W4313292225C33923547 @default.
• W4313292225 hasConceptScore W4313292225C41625074 @default.
• W4313292225 hasConceptScore W4313292225C515207424 @default.
• W4313292225 hasConceptScore W4313292225C534586 @default.
• W4313292225 hasConceptScore W4313292225C55493867 @default.
• W4313292225 hasConceptScore W4313292225C57711820 @default.
• W4313292225 hasConceptScore W4313292225C79879829 @default.
• W4313292225 hasConceptScore W4313292225C86803240 @default.
• W4313292225 hasConceptScore W4313292225C95444343 @default.

• next