Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313293407> ?p ?o ?g. }
- W4313293407 abstract "ABSTRACT How steroid hormone receptors (SHRs) orchestrate transcriptional activity remains only partly understood. Upon activation, SHRs bind the genome and recruit their co-regulators, crucial to induce gene expression. However, it remains unknown which components of the SHR-recruited co-regulator complex are essential to drive transcription following hormonal stimuli. Through a FACS-based genome-wide CRISPR screen, we comprehensively dissected the Glucocorticoid Receptor (GR) co-regulatory complex involved in gene-target regulation. We describe a novel functional cross-talk between PAXIP1 and the cohesin subunit STAG2 that is critical for regulation of gene expression by GR. Without altering the GR cistrome, PAXIP1 and STAG2 depletion alter the GR transcriptome, by impairing the recruitment of 3D-genome organization proteins to the GR complex. Importantly, we demonstrate that PAXIP1 is required for stability of cohesin on the genome, its localization to GR-occupied sites, and maintenance of enhancer-promoter interactions. Moreover, in lung cancer, where GR acts as tumor suppressor, PAXIP1/STAG2 loss enhances GR-mediated tumor suppressor activity by modifying local chromatin interactions. All together, we introduce PAXIP1 and STAG2 as novel co-regulators of GR, required to maintain 3D-genome architecture and drive the GR transcriptional programme following hormonal stimuli." @default.
- W4313293407 created "2023-01-06" @default.
- W4313293407 creator A5004099453 @default.
- W4313293407 creator A5006945495 @default.
- W4313293407 creator A5007762420 @default.
- W4313293407 creator A5010181844 @default.
- W4313293407 creator A5011590978 @default.
- W4313293407 creator A5014328327 @default.
- W4313293407 creator A5020578467 @default.
- W4313293407 creator A5027706602 @default.
- W4313293407 creator A5029485498 @default.
- W4313293407 creator A5042855795 @default.
- W4313293407 creator A5061479974 @default.
- W4313293407 creator A5062641643 @default.
- W4313293407 creator A5069691714 @default.
- W4313293407 creator A5077577302 @default.
- W4313293407 creator A5078070747 @default.
- W4313293407 creator A5078298172 @default.
- W4313293407 creator A5079448065 @default.
- W4313293407 creator A5084927840 @default.
- W4313293407 creator A5070233211 @default.
- W4313293407 date "2022-12-27" @default.
- W4313293407 modified "2023-09-30" @default.
- W4313293407 title "PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription" @default.
- W4313293407 cites W1606047558 @default.
- W4313293407 cites W1919133853 @default.
- W4313293407 cites W1963958393 @default.
- W4313293407 cites W1972307085 @default.
- W4313293407 cites W1973036877 @default.
- W4313293407 cites W1973260880 @default.
- W4313293407 cites W1977709885 @default.
- W4313293407 cites W1987523347 @default.
- W4313293407 cites W1994680231 @default.
- W4313293407 cites W2007825702 @default.
- W4313293407 cites W2015477868 @default.
- W4313293407 cites W2036054914 @default.
- W4313293407 cites W2041756861 @default.
- W4313293407 cites W2043363450 @default.
- W4313293407 cites W2048336257 @default.
- W4313293407 cites W2049283940 @default.
- W4313293407 cites W2057267524 @default.
- W4313293407 cites W2072194885 @default.
- W4313293407 cites W2078455244 @default.
- W4313293407 cites W2085633321 @default.
- W4313293407 cites W2100122648 @default.
- W4313293407 cites W2103441770 @default.
- W4313293407 cites W2104836314 @default.
- W4313293407 cites W2108234281 @default.
- W4313293407 cites W2125362831 @default.
- W4313293407 cites W2130560229 @default.
- W4313293407 cites W2134526812 @default.
- W4313293407 cites W2135060880 @default.
- W4313293407 cites W2144091055 @default.
- W4313293407 cites W2154872843 @default.
- W4313293407 cites W2154968323 @default.
- W4313293407 cites W2161797274 @default.
- W4313293407 cites W2165833564 @default.
- W4313293407 cites W2169318796 @default.
- W4313293407 cites W2170723451 @default.
- W4313293407 cites W2170830174 @default.
- W4313293407 cites W2171808845 @default.
- W4313293407 cites W2179438025 @default.
- W4313293407 cites W2224926542 @default.
- W4313293407 cites W2252568502 @default.
- W4313293407 cites W2266235508 @default.
- W4313293407 cites W2269247182 @default.
- W4313293407 cites W2270544154 @default.
- W4313293407 cites W2298612765 @default.
- W4313293407 cites W2345879537 @default.
- W4313293407 cites W2404025800 @default.
- W4313293407 cites W2463195069 @default.
- W4313293407 cites W2531506996 @default.
- W4313293407 cites W2598803157 @default.
- W4313293407 cites W2611886390 @default.
- W4313293407 cites W2751019821 @default.
- W4313293407 cites W2755732042 @default.
- W4313293407 cites W2756240008 @default.
- W4313293407 cites W2806700712 @default.
- W4313293407 cites W2882996798 @default.
- W4313293407 cites W2890448483 @default.
- W4313293407 cites W2904042998 @default.
- W4313293407 cites W2904226822 @default.
- W4313293407 cites W2949389238 @default.
- W4313293407 cites W2964849163 @default.
- W4313293407 cites W2965516429 @default.
- W4313293407 cites W2973094225 @default.
- W4313293407 cites W2982240859 @default.
- W4313293407 cites W2982390087 @default.
- W4313293407 cites W2998399076 @default.
- W4313293407 cites W3042260087 @default.
- W4313293407 cites W3081722047 @default.
- W4313293407 cites W3087672893 @default.
- W4313293407 cites W3114206138 @default.
- W4313293407 cites W3128048891 @default.
- W4313293407 cites W3136389052 @default.
- W4313293407 cites W3153703639 @default.
- W4313293407 cites W3156113107 @default.
- W4313293407 cites W3179098870 @default.
- W4313293407 cites W3208691473 @default.
- W4313293407 cites W4220778487 @default.