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• W4313294402 abstract "Abstract The sensitive and precise quantitative determination of thrombin is important for both fundamental research and clinical diagnostics of hypoxic ischemic encephalopathy because it is a key biological molecule in hemostasis and hemolysis. Herein, we depict a sensitive and label-free thrombin detection approach by taking the advantages of aptamer’s superior capability to bind with thrombin and the high efficiency of three-way junction initiated dual signal recycle. In this method, a capture probe which is inserted with an aptamer sequence is designed to specifically identify thrombin molecule and facilitate the signal amplification. Based on the DNA polymerase and endonuclease Nb.BbvCI-assisted chain extension, a large amount of single-strand DNA sequences that can fold into G-quadruplex are produced to specifically recognize commercial fluorescent dye thioflavin T for signal generation. Consequently, the approach exhibits a high detection sensitivity with the limit of detection as low as 768 fM, holding a great promise for detection of thrombin and disease diagnosis in the clinic." @default.
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• W4313294402 date "2022-12-16" @default.
• W4313294402 modified "2023-10-14" @default.
• W4313294402 title "Ultrasensitive thrombin sensing platform based on three-way junction initiated dual signal amplification" @default.
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• W4313294402 doi "https://doi.org/10.1186/s40543-022-00362-1" @default.
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