Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313294807> ?p ?o ?g. }
- W4313294807 endingPage "622" @default.
- W4313294807 startingPage "622" @default.
- W4313294807 abstract "Excessive stress plays a critical role in the pathogenesis of mood disorders such as depression. Fermented natural products have recently attracted attention because of their health benefits. We evaluated the antidepressant-like efficacy of fermented Perilla frutescens (FPF), and its underlying mechanisms, in sleep deprivation (SD)-induced stress mice. SD-stressed mice revealed a remarkable increase in the immobility time in both forced swimming test and tail suspension test; this increase was ameliorated by treatment with FPF at doses of 100 and 150 mg/kg. FPF treatment also reduced the level of stress hormones such as corticosterone and adrenocorticotropic hormone. Additionally, FPF increased the levels of serotonin and dopamine which were significantly decreased in the brain tissues of SD-stressed mice. The increased expression of proinflammatory cytokines, such as TNF-α and IL1β, and the decreased expression of brain-derived neurotrophic factor (BDNF) in the stressed mice were significantly reversed by FPF treatment. Furthermore, FPF also increased phosphorylation of tropomyosin receptor kinase B (TrkB), extracellular regulated protein kinase (ERK), and cAMP response element binding protein (CREB). Among the six components isolated from FPF, protocatechuic acid and luteolin-7-O-glucuronide exhibited significant antidepressant-like effects, suggesting that they are major active components. These findings suggest that FPF has therapeutic potential for SD-induced stress, by correcting dysfunction of hypothalamic-pituitary-adrenal axis and modulating the BDNF/TrkB/ERK/CREB signaling pathway." @default.
- W4313294807 created "2023-01-06" @default.
- W4313294807 creator A5027115200 @default.
- W4313294807 creator A5030341663 @default.
- W4313294807 creator A5041083866 @default.
- W4313294807 creator A5043855440 @default.
- W4313294807 creator A5063797052 @default.
- W4313294807 creator A5072362725 @default.
- W4313294807 creator A5091523301 @default.
- W4313294807 date "2022-12-30" @default.
- W4313294807 modified "2023-09-26" @default.
- W4313294807 title "Fermented Perilla frutescens Ameliorates Depression-like Behavior in Sleep-Deprivation-Induced Stress Model" @default.
- W4313294807 cites W1481228963 @default.
- W4313294807 cites W1516330047 @default.
- W4313294807 cites W1645317850 @default.
- W4313294807 cites W1659530875 @default.
- W4313294807 cites W195205823 @default.
- W4313294807 cites W1969065116 @default.
- W4313294807 cites W1987025276 @default.
- W4313294807 cites W1987912134 @default.
- W4313294807 cites W1990598466 @default.
- W4313294807 cites W2002700336 @default.
- W4313294807 cites W2003982930 @default.
- W4313294807 cites W2007311043 @default.
- W4313294807 cites W2007636259 @default.
- W4313294807 cites W2013184659 @default.
- W4313294807 cites W2013443414 @default.
- W4313294807 cites W2014904526 @default.
- W4313294807 cites W2015859900 @default.
- W4313294807 cites W2019245948 @default.
- W4313294807 cites W2023288605 @default.
- W4313294807 cites W2027304084 @default.
- W4313294807 cites W2028429075 @default.
- W4313294807 cites W2030859315 @default.
- W4313294807 cites W2032017343 @default.
- W4313294807 cites W2033073534 @default.
- W4313294807 cites W2033615392 @default.
- W4313294807 cites W2039628081 @default.
- W4313294807 cites W2041190857 @default.
- W4313294807 cites W2043217368 @default.
- W4313294807 cites W2050066956 @default.
- W4313294807 cites W2052097044 @default.
- W4313294807 cites W2056771515 @default.
- W4313294807 cites W2062000743 @default.
- W4313294807 cites W2062989629 @default.
- W4313294807 cites W2069692485 @default.
- W4313294807 cites W2072457730 @default.
- W4313294807 cites W2081379318 @default.
- W4313294807 cites W2082464174 @default.
- W4313294807 cites W2083207963 @default.
- W4313294807 cites W2086248379 @default.
- W4313294807 cites W2089198034 @default.
- W4313294807 cites W2089619405 @default.
- W4313294807 cites W2091912666 @default.
- W4313294807 cites W2098906620 @default.
- W4313294807 cites W2107195919 @default.
- W4313294807 cites W2109309568 @default.
- W4313294807 cites W2111665528 @default.
- W4313294807 cites W2113161144 @default.
- W4313294807 cites W2123886424 @default.
- W4313294807 cites W2124058238 @default.
- W4313294807 cites W2124814518 @default.
- W4313294807 cites W2129705910 @default.
- W4313294807 cites W2135055168 @default.
- W4313294807 cites W2148450715 @default.
- W4313294807 cites W2151595908 @default.
- W4313294807 cites W2155686640 @default.
- W4313294807 cites W2163419022 @default.
- W4313294807 cites W2166667138 @default.
- W4313294807 cites W2169294911 @default.
- W4313294807 cites W2171043804 @default.
- W4313294807 cites W2180747197 @default.
- W4313294807 cites W2232387087 @default.
- W4313294807 cites W2309165118 @default.
- W4313294807 cites W2346391128 @default.
- W4313294807 cites W2512630553 @default.
- W4313294807 cites W2555784431 @default.
- W4313294807 cites W2621911198 @default.
- W4313294807 cites W2756331044 @default.
- W4313294807 cites W2782432378 @default.
- W4313294807 cites W2787791202 @default.
- W4313294807 cites W2792694163 @default.
- W4313294807 cites W2810237733 @default.
- W4313294807 cites W2898150668 @default.
- W4313294807 cites W2901734506 @default.
- W4313294807 cites W2909025052 @default.
- W4313294807 cites W2966371943 @default.
- W4313294807 cites W2970852449 @default.
- W4313294807 cites W2989715299 @default.
- W4313294807 cites W3003566286 @default.
- W4313294807 cites W3007839682 @default.
- W4313294807 cites W3008014376 @default.
- W4313294807 cites W3034596262 @default.
- W4313294807 cites W3037491078 @default.
- W4313294807 cites W3080602208 @default.
- W4313294807 cites W3092122284 @default.
- W4313294807 cites W3106438165 @default.
- W4313294807 cites W3111686686 @default.