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- W4313296788 abstract "Murburn concept constitutes the thesis that diffusible reactive species or (DRS) are obligatorily involved in routine metabolic and physiological activities. Murzymes are defined as biomolecules/proteins that generate/modulate/sustain/utilize DRS. Murburn post-translational modifications (PTMs) result because murburn/murzyme functionalism is integral to cellular existence, which must incorporate the inherently stochastic nature of operations mediated by DRS. Due to the earlier/inertial stigmatic perception that DRS are mere agents of chaos, several such outcomes were either understood as deterministic modulations sponsored by house-keeping enzymes or deemed as unregulated non-enzymatic events resulting out of ‘oxidative stress’. In the current review, I dispel the myths around DRS-functions, and undertake systematic parsing and analyses of murburn modifications of proteins. Although it is impossible to demarcate all PTMs into the classical or murburn modalities, telltale signs of the latter are evident from the relative inaccessibility of the locus, non-specificities and mechanistic details. It is pointed out that while many murburn PTMs may be harmless, some others could have deleterious or beneficial physiological implications. Some details of reversible/irreversible modifications of amino acid residues and cofactors that may be subjected to phosphorylation, halogenation, glycosylation, alkylation/acetylation, hydroxylation/oxidation, etc. are listed, along with citations of select proteins where such modifications have been reported. The contexts of these modifications and their significance in (patho)physiology/aging and therapy are also presented. With more balanced explorations and statistically verified data, a definitive understanding of normal versus pathological contexts of murburn modifications would be obtainable in the future." @default.
- W4313296788 created "2023-01-06" @default.
- W4313296788 creator A5063916487 @default.
- W4313296788 date "2022-12-28" @default.
- W4313296788 modified "2023-10-17" @default.
- W4313296788 title "Murburn modifications of proteins" @default.
- W4313296788 doi "https://doi.org/10.31219/osf.io/p6k3z" @default.
- W4313296788 hasPublicationYear "2022" @default.
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