Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313298905> ?p ?o ?g. }
- W4313298905 abstract "SUMMARY The reduced pathogenicity of the omicron BA.1 sub-lineage compared to earlier variants is well described, although whether such attenuation is retained for later variants like BA.5 and XBB remains controversial. We show that BA.5 and XBB isolates were significantly more pathogenic in K18-hACE2 mice than a BA.1 isolate, showing increased neuroinvasiveness, resulting in fulminant brain infection and mortality, similar to that seen for original ancestral isolates. BA.5 also infected human cortical brain organoids to a greater extent than the BA.1 and original ancestral isolates. In the brains of mice, neurons were the main target of infection, and in human organoids neuronal progenitor cells and immature neurons were infected. Although fulminant brain infection is not a feature of COVID-19, evidence for brain infection and brain damage in some COVID-19 patients with severe disease is becoming compelling, with the results herein suggesting that evolving omicron variants may have increasing intrinsic neuropathogenic potential." @default.
- W4313298905 created "2023-01-06" @default.
- W4313298905 creator A5013718219 @default.
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- W4313298905 creator A5085885589 @default.
- W4313298905 date "2022-12-25" @default.
- W4313298905 modified "2023-10-17" @default.
- W4313298905 title "Omicron BA.5 infects human brain organoids and is neuroinvasive and lethal in K18-hACE2 mice" @default.
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