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• W4313298931 abstract "Summary The Na + channels that are important for action potentials show rapid inactivation, a state in which they do not conduct, although the membrane potential remains depolarized 1,2 . Rapid inactivation is a determinant of millisecond scale phenomena, such as spike shape and refractory period. Na + channels also inactivate orders of magnitude more slowly, and therefore have impacts on excitability over much longer time scales than those of a single spike or a single inter-spike interval 3-9 . Here, we focus on the contribution of slow inactivation to the resilience of axonal excitability 10,11 when ion channels are unevenly distributed across the axonal membrane. We study models in which the voltage-gated Na + and K + channels are unevenly distributed along axons with different variances, capturing the heterogeneity that biological axons display 12 . In the absence of slow inactivation many conductance distributions result in spontaneous tonic activity. Faithful axonal propagation is achieved with the introduction of Na + channel slow inactivation. This “normalization” effect depends on relations between the kinetics of slow inactivation and the firing frequency. Consequently, neurons with characteristically different firing frequencies will need to implement different sets of channel properties to achieve resilience. The results of this study demonstrate the importance of the intrinsic biophysical properties of ion channels in normalizing axonal function. Highlights Variation in ion channel density in axons may compromise axonal spike propagation. Slow inactivation of Na + channels modulates their availability. Na + channel slow inactivation increases the reliability of spike propagation. Normalization by slow inactivation can compensate for uneven channel distributions." @default.
• W4313298931 created "2023-01-06" @default.
• W4313298931 creator A5042965930 @default.
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• W4313298931 date "2022-12-26" @default.
• W4313298931 modified "2023-09-27" @default.
• W4313298931 title "Sodium channel slow inactivation normalizes firing in axons with uneven conductance distributions" @default.
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• W4313298931 doi "https://doi.org/10.1101/2022.12.26.521945" @default.
• W4313298931 hasPublicationYear "2022" @default.
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