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- W4313303860 endingPage "110993" @default.
- W4313303860 startingPage "110993" @default.
- W4313303860 abstract "Peroxynitrite (ONOO−), a potent oxidant, plays an important regulation role in different physiopathological processes. Its overproduction can potentially cause several diseases. Therefore, being able to accurately and selectively monitor ONOO− could help elucidate the interaction and function of ONOO− in physiological and pathological processes. Herein, a novel naphthalimide derived ratiometric fluorescent probe was successfully designed and synthesized for monitoring ONOO− in RAW 264.7 macrophage cells and zebrafish. The probe showed highly selective towards ONOO− with satisfactory sensitivity (detection limit: 0.32 μM) and a significant 15 - fold enhancement of fluorescence ratio accompanied with a large blue shift of 110 nm. In addition, further biological experimental studies showed that the probe could track ONOO− in RAW 264.7 macrophage cells and zebrafish animal models with specific sensitivity and reliability. Therefore, the probe can be expected to be a biological tool for developing the role of ONOO− in physiological systems in the future." @default.
- W4313303860 created "2023-01-06" @default.
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- W4313303860 date "2023-02-01" @default.
- W4313303860 modified "2023-10-13" @default.
- W4313303860 title "A simple highly selective ratiometric fluorescent probe for detection of peroxynitrite and its bioimaging applications" @default.
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- W4313303860 doi "https://doi.org/10.1016/j.dyepig.2022.110993" @default.
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