FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313304076> ?p ?o ?g. }

• W4313304076 abstract "Physiological states of bacterial cells exhibit a wide spectrum of timescale. Under nutrient-rich conditions, most of the cells in an isogenic bacterial population grow at certain rates, while a small subpopulation sometimes falls into a dormant state where the growth rates slow down by orders of magnitude. The dormant cells have unique characteristics: The metabolic activity is quite slow, and the dormant cells typically exhibit a high tolerance for a range of stresses, such as antibiotics applications. To reveal the origins of such heterogeneity of timescales, we constructed a kinetic model of Escherichia coli central carbon metabolism, including the dynamics of the energy currency molecules, and asked if perturbations of the metabolites' concentrations lead to the distinct metabolic states. By numerically studying the relaxation dynamics, we found that the model robustly exhibits two qualitatively distinct relaxation dynamics depending on the initial conditions generated by the perturbations. In the first type, the concentrations of metabolites reach the steady state quickly, resembling the growing dynamics. On the other hand, the other type of dynamics takes a much longer time to reach the steady state, and during the relaxation, cell growth almost halts, reminding us of the dormant cells. In order to unveil the mechanism of distinct behaviors, we reduced the metabolic network model into a minimal model without losing the emergence of distinct dynamics. Analytical and numerical studies of the two-variable minimal model revealed the necessary conditions for the distinct behavior, namely, the depletion of energy due to the futile cycle and its nonuniform impact on the kinetics because of the coexistence of the energy currency-coupled and uncoupled reactions as well as branching of the network. The result is consistent with the experimental reports that the dormant cells commonly exhibit low ATP levels and provides a possible explanation for the appearance of dormant cells that causes antibiotic persistence." @default.
• W4313304076 created "2023-01-06" @default.
• W4313304076 creator A5011830037 @default.
• W4313304076 creator A5088702916 @default.
• W4313304076 date "2022-12-30" @default.
• W4313304076 modified "2023-10-14" @default.
• W4313304076 title "Emergence of growth and dormancy from a kinetic model of the <i>Escherichia coli</i> central carbon metabolism" @default.
• W4313304076 cites W1519685185 @default.
• W4313304076 cites W1665355332 @default.
• W4313304076 cites W1768808606 @default.
• W4313304076 cites W1862094217 @default.
• W4313304076 cites W1909963107 @default.
• W4313304076 cites W1982958351 @default.
• W4313304076 cites W1985002373 @default.
• W4313304076 cites W2004252769 @default.
• W4313304076 cites W2034738976 @default.
• W4313304076 cites W2034961255 @default.
• W4313304076 cites W2038574237 @default.
• W4313304076 cites W2038597461 @default.
• W4313304076 cites W2053339983 @default.
• W4313304076 cites W2072281659 @default.
• W4313304076 cites W2073824449 @default.
• W4313304076 cites W2075329036 @default.
• W4313304076 cites W2086604775 @default.
• W4313304076 cites W2090628795 @default.
• W4313304076 cites W2091087653 @default.
• W4313304076 cites W2096692298 @default.
• W4313304076 cites W2099925845 @default.
• W4313304076 cites W2102919205 @default.
• W4313304076 cites W2106895423 @default.
• W4313304076 cites W2115419697 @default.
• W4313304076 cites W2115606218 @default.
• W4313304076 cites W2124562476 @default.
• W4313304076 cites W2124786260 @default.
• W4313304076 cites W2125396196 @default.
• W4313304076 cites W2127878017 @default.
• W4313304076 cites W2137956358 @default.
• W4313304076 cites W2145676608 @default.
• W4313304076 cites W2148323109 @default.
• W4313304076 cites W2152540020 @default.
• W4313304076 cites W2158408911 @default.
• W4313304076 cites W2167244112 @default.
• W4313304076 cites W2167900930 @default.
• W4313304076 cites W2208222770 @default.
• W4313304076 cites W2298249827 @default.
• W4313304076 cites W2336504120 @default.
• W4313304076 cites W2523512393 @default.
• W4313304076 cites W2559752444 @default.
• W4313304076 cites W2561960911 @default.
• W4313304076 cites W2586386056 @default.
• W4313304076 cites W2592202891 @default.
• W4313304076 cites W2766821438 @default.
• W4313304076 cites W2767592395 @default.
• W4313304076 cites W2802858971 @default.
• W4313304076 cites W2940117744 @default.
• W4313304076 cites W3033803671 @default.
• W4313304076 cites W3101858502 @default.
• W4313304076 cites W3127310298 @default.
• W4313304076 cites W3152566676 @default.
• W4313304076 cites W3165625814 @default.
• W4313304076 cites W3214730028 @default.
• W4313304076 cites W4224275475 @default.
• W4313304076 cites W4244856576 @default.
• W4313304076 cites W4294216483 @default.
• W4313304076 doi "https://doi.org/10.1103/physrevresearch.4.043223" @default.
• W4313304076 hasPublicationYear "2022" @default.
• W4313304076 type Work @default.
• W4313304076 citedByCount "1" @default.
• W4313304076 crossrefType "journal-article" @default.
• W4313304076 hasAuthorship W4313304076A5011830037 @default.
• W4313304076 hasAuthorship W4313304076A5088702916 @default.
• W4313304076 hasBestOaLocation W43133040761 @default.
• W4313304076 hasConcept C100701293 @default.
• W4313304076 hasConcept C104317684 @default.
• W4313304076 hasConcept C121332964 @default.
• W4313304076 hasConcept C12554922 @default.
• W4313304076 hasConcept C144024400 @default.
• W4313304076 hasConcept C145912823 @default.
• W4313304076 hasConcept C147789679 @default.
• W4313304076 hasConcept C149923435 @default.
• W4313304076 hasConcept C169760540 @default.
• W4313304076 hasConcept C185592680 @default.
• W4313304076 hasConcept C186060115 @default.
• W4313304076 hasConcept C24890656 @default.
• W4313304076 hasConcept C2776029896 @default.
• W4313304076 hasConcept C2908647359 @default.
• W4313304076 hasConcept C3527866 @default.
• W4313304076 hasConcept C547475151 @default.
• W4313304076 hasConcept C55493867 @default.
• W4313304076 hasConcept C59822182 @default.
• W4313304076 hasConcept C62231903 @default.
• W4313304076 hasConcept C8171440 @default.
• W4313304076 hasConcept C86803240 @default.
• W4313304076 hasConceptScore W4313304076C100701293 @default.
• W4313304076 hasConceptScore W4313304076C104317684 @default.
• W4313304076 hasConceptScore W4313304076C121332964 @default.
• W4313304076 hasConceptScore W4313304076C12554922 @default.
• W4313304076 hasConceptScore W4313304076C144024400 @default.
• W4313304076 hasConceptScore W4313304076C145912823 @default.
• W4313304076 hasConceptScore W4313304076C147789679 @default.

• next