FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313304211> ?p ?o ?g. }

• W4313304211 endingPage "e067159" @default.
• W4313304211 startingPage "e067159" @default.
• W4313304211 abstract "Introduction The growing worldwide prevalence of Alzheimer’s disease (AD) and the lack of effective treatments pose a dire medical challenge. Sleep disruption is also prevalent in the ageing population and is increasingly recognised as a risk factor and an early sign of AD. The ALFASleep project aims to characterise sleep with subjective and objective measurements in cognitively unimpaired middle/late middle-aged adults at increased risk of AD who are phenotyped with fluid and neuroimaging AD biomarkers. This will contribute to a better understanding of the pathophysiological mechanisms linking sleep with AD, thereby paving the way for the development of non-invasive biomarkers and preventive strategies targeting sleep. Methods and analysis We will invite 200 participants enrolled in the ALFA+ (for ALzheimer and FAmilies) prospective observational study to join the ALFASleep study. ALFA+ participants are cognitively unimpaired middle-aged/late middle-aged adults who are followed up every 3 years with a comprehensive set of evaluations including neuropsychological tests, blood and cerebrospinal fluid (CSF) sampling, and MRI and positron emission tomography acquisition. ALFASleep participants will be additionally characterised with actigraphy and CSF–orexin-A measurements, and a subset (n=90) will undergo overnight polysomnography. We will test associations of sleep measurements and CSF–orexin-A with fluid biomarkers of AD and glial activation, neuroimaging outcomes and cognitive performance. In case we found any associations, we will test whether changes in AD and/or glial activation markers mediate the association between sleep and neuroimaging or cognitive outcomes and whether sleep mediates associations between CSF–orexin-A and AD biomarkers. Ethics and dissemination The ALFASleep study protocol has been approved by the independent Ethics Committee Parc de Salut Mar, Barcelona (2018/8207/I). All participants have signed a written informed consent before their inclusion (approved by the same ethics committee). Study findings will be presented at national and international conferences and submitted for publication in peer-reviewed journals. Trial registration number NCT04932473 ." @default.
• W4313304211 created "2023-01-06" @default.
• W4313304211 creator A5002115515 @default.
• W4313304211 creator A5003332363 @default.
• W4313304211 creator A5008974630 @default.
• W4313304211 creator A5016908006 @default.
• W4313304211 creator A5020077464 @default.
• W4313304211 creator A5021685997 @default.
• W4313304211 creator A5022818856 @default.
• W4313304211 creator A5024868777 @default.
• W4313304211 creator A5025313057 @default.
• W4313304211 creator A5036068671 @default.
• W4313304211 creator A5036130181 @default.
• W4313304211 creator A5036675359 @default.
• W4313304211 creator A5043449184 @default.
• W4313304211 creator A5046373942 @default.
• W4313304211 creator A5046475011 @default.
• W4313304211 creator A5047370419 @default.
• W4313304211 creator A5065146784 @default.
• W4313304211 creator A5066508710 @default.
• W4313304211 creator A5076043002 @default.
• W4313304211 creator A5080005304 @default.
• W4313304211 creator A5083845354 @default.
• W4313304211 creator A5085734630 @default.
• W4313304211 creator A5085979291 @default.
• W4313304211 creator A5090583761 @default.
• W4313304211 date "2022-12-01" @default.
• W4313304211 modified "2023-10-17" @default.
• W4313304211 title "Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer’s disease (ALFASleep project): protocol for an observational study" @default.
• W4313304211 cites W1551043384 @default.
• W4313304211 cites W1579130254 @default.
• W4313304211 cites W1841850981 @default.
• W4313304211 cites W1913092771 @default.
• W4313304211 cites W1949141612 @default.
• W4313304211 cites W1958698361 @default.
• W4313304211 cites W1966645764 @default.
• W4313304211 cites W1967822713 @default.
• W4313304211 cites W197066864 @default.
• W4313304211 cites W1982924671 @default.
• W4313304211 cites W1991934169 @default.
• W4313304211 cites W1992999217 @default.
• W4313304211 cites W1999009790 @default.
• W4313304211 cites W1999725491 @default.
• W4313304211 cites W2000555003 @default.
• W4313304211 cites W2004927913 @default.
• W4313304211 cites W2007092083 @default.
• W4313304211 cites W2007861486 @default.
• W4313304211 cites W2008344154 @default.
• W4313304211 cites W2013333500 @default.
• W4313304211 cites W2015603515 @default.
• W4313304211 cites W2016069734 @default.
• W4313304211 cites W2024830095 @default.
• W4313304211 cites W2027160502 @default.
• W4313304211 cites W2030353060 @default.
• W4313304211 cites W2030923967 @default.
• W4313304211 cites W2048444499 @default.
• W4313304211 cites W2053369816 @default.
• W4313304211 cites W2065565096 @default.
• W4313304211 cites W2067965293 @default.
• W4313304211 cites W2071274868 @default.
• W4313304211 cites W2072500831 @default.
• W4313304211 cites W2072533873 @default.
• W4313304211 cites W2087131710 @default.
• W4313304211 cites W2092938587 @default.
• W4313304211 cites W2096429475 @default.
• W4313304211 cites W2105071925 @default.
• W4313304211 cites W2109053359 @default.
• W4313304211 cites W2115017507 @default.
• W4313304211 cites W2121446634 @default.
• W4313304211 cites W2124030567 @default.
• W4313304211 cites W2127567236 @default.
• W4313304211 cites W2143790126 @default.
• W4313304211 cites W2151487996 @default.
• W4313304211 cites W2153203890 @default.
• W4313304211 cites W2160311930 @default.
• W4313304211 cites W2161166547 @default.
• W4313304211 cites W2171250577 @default.
• W4313304211 cites W2273682194 @default.
• W4313304211 cites W2293300637 @default.
• W4313304211 cites W2297783832 @default.
• W4313304211 cites W2301075806 @default.
• W4313304211 cites W2316666697 @default.
• W4313304211 cites W2400677330 @default.
• W4313304211 cites W2485218258 @default.
• W4313304211 cites W2513816257 @default.
• W4313304211 cites W2531057230 @default.
• W4313304211 cites W2547784142 @default.
• W4313304211 cites W2561913540 @default.
• W4313304211 cites W2576308650 @default.
• W4313304211 cites W2582524520 @default.
• W4313304211 cites W2595939095 @default.
• W4313304211 cites W2611695796 @default.
• W4313304211 cites W2730282614 @default.
• W4313304211 cites W2735226312 @default.
• W4313304211 cites W2736714727 @default.
• W4313304211 cites W2749492625 @default.
• W4313304211 cites W2767862404 @default.
• W4313304211 cites W2773346142 @default.

• next