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- W4313305788 abstract "Abstract DC differentiated through culture with GM-CSF are used in many clinically promising applications including vaccines. However, the developmental timeline during which specific stimulatory or immunosuppressive functions are acquired by these cells is poorly understood. Here, we developed a method of isolating progenitor populations at specific stages of development to monitor their phenotype and function. Bone marrow cells were cultured in GM-CSF for three days, then sorted based on Ly6c and CSF-1R (CD115) expression, two hallmarks of myeloid cell development. We then monitored the developmental progression and differentiation of each population based on the expression of these proteins as well as several other hallmarks of the dendritic cell phenotype. We measured their gene expression profiles by qRT-PCR and their response to inflammatory stimuli at each stage of development. Through this analysis, we have identified five distinct cell types representative of Common Myeloid Progenitors (CMP), Granulocyte Macrophage Progenitors (GMP), Monocytes, inflammatory DC (iDC), and a novel dendritic cell precursor which is phenotypically and functionally distinct from previously described myeloid cells. Our findings suggest this novel cell type, Inflammatory DC precursor (IDP), arises from monocytes and serves as an immediate precursor to immature inflammatory DCs. These studies will aid in the refinement of protocols to acquire cells for specific clinical applications." @default.
- W4313305788 created "2023-01-06" @default.
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- W4313305788 date "2015-05-01" @default.
- W4313305788 modified "2023-09-25" @default.
- W4313305788 title "Identification and characterization of a novel inflammatory DC precursor (HEM5P.235)" @default.
- W4313305788 doi "https://doi.org/10.4049/jimmunol.194.supp.120.15" @default.
- W4313305788 hasPublicationYear "2015" @default.
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