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- W4313305814 abstract "Abstract Beside its several immunological roles, the spleen functions as an accessory hemopoetic tissue. This activity is restricted to the red pulp, which is influenced by transcription factor Nkx2-3. It is not yet known how the absence of Nkx2-3 affects the inducible splenic hemopoesis. In this work we studied how Nkx2-3 affects splenic stress hemopoiesis after inducing acute anemia and forced megakaryocyte differentiation using TPO-receptor agonist N-plate treatment. In untreated Nkx2-3 deficient mice the Ter119 erythroid cell frequency was higher in the bone marrow than in BALB/c controls, but it was lower in the spleen. Following anemization the number of erythroid cells increased in the bone marrow and spleen of BALB/c mice, whereas in Nkx2-3 KO mice erythroid expansion was only observed in the bone marrow, the splenic Ter119-positive erythroid compartment further decreased. The serum erythropoietin level increased in both groups and the highest level was in the anemic Nkx2-3 knockout group. Treatment with N-plate increased megakaryocyte number in wild-type BALB/c mice in both the bone marrow and spleen whereas in Nkx2-3 KO mice the spleen was resistant. These results show that Nkx2-3 plays a crucial role in the development of splenic stromal microenvironment necessary for supporting the extramedullary hematopoiesis in a tissue-specific manner." @default.
- W4313305814 created "2023-01-06" @default.
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- W4313305814 date "2015-05-01" @default.
- W4313305814 modified "2023-10-01" @default.
- W4313305814 title "Tissue-specific impairment of stress hematopoiesis and megakaryocytopoiesis in mice deficient for Nkx2-3 homeodomain transcription factor (HEM5P.230)" @default.
- W4313305814 doi "https://doi.org/10.4049/jimmunol.194.supp.120.10" @default.
- W4313305814 hasPublicationYear "2015" @default.
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