Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313305828> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4313305828 endingPage "2466" @default.
- W4313305828 startingPage "2461" @default.
- W4313305828 abstract "Keratinocytes play an important role in wound healing; however, less is known about skin keratinocytes in patients with type 2 diabetes mellitus (T2DM). Therefore, this study aimed to search for the transcriptional characteristics of keratinocytes at the single-cell level from T2DM patients, and to provide experimental data for identifying the pathological mechanisms of keratinocytes under pathological conditions.We performed single-cell RNA sequencing on the skin tissue from two T2DM patients and one patient without diabetes-induced trauma using the BD Rhapsody™ Single-Cell Analysis System. With the help of bioinformatics R-based single-cell analysis software, we analyzed the results of single-cell sequencing to identify the single-cell subsets and transcriptional characteristics of keratinocytes at the single-cell level, including Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyzes.In this study, we found specific highly expressed signature keratinocyte-related genes. We analyzed the transcriptome of keratinocytes from experimental and control groups and screened a total of 356 differential genes, which were subject to bioinformatics analysis. Enriched pathways included oxidative phosphorylation, antigen processing and presentation, prion and Huntingtons' diseases, bacterial invasion of epithelial cells, thermogenesis, vasopressin-regulated water reabsorption, and protein processing in the endoplasmic reticulum.This study revealed the characteristics of keratinocytes at the single-cell level and screened a group of differentially expressed genes related to T2DM-associated keratinocytes, oxidative phosphorylation, cytokine receptor interactions, prion diseases, and other signaling pathways." @default.
- W4313305828 created "2023-01-06" @default.
- W4313305828 creator A5000821582 @default.
- W4313305828 creator A5003554962 @default.
- W4313305828 creator A5004003643 @default.
- W4313305828 creator A5048725712 @default.
- W4313305828 creator A5060239423 @default.
- W4313305828 creator A5067876890 @default.
- W4313305828 creator A5074586582 @default.
- W4313305828 date "2022-10-20" @default.
- W4313305828 modified "2023-09-25" @default.
- W4313305828 title "Characteristic analysis of skin keratinocytes in patients with type 2 diabetes based on the single-cell levels" @default.
- W4313305828 cites W2113805681 @default.
- W4313305828 cites W2578363228 @default.
- W4313305828 cites W2739655881 @default.
- W4313305828 cites W2783751627 @default.
- W4313305828 cites W2795539529 @default.
- W4313305828 cites W2808305854 @default.
- W4313305828 cites W2811171873 @default.
- W4313305828 cites W2890876748 @default.
- W4313305828 cites W2915171406 @default.
- W4313305828 cites W2926010705 @default.
- W4313305828 cites W2961304458 @default.
- W4313305828 cites W2980355674 @default.
- W4313305828 cites W2998869532 @default.
- W4313305828 cites W3000145506 @default.
- W4313305828 cites W3000932254 @default.
- W4313305828 cites W3004557319 @default.
- W4313305828 cites W3010569170 @default.
- W4313305828 cites W3010625438 @default.
- W4313305828 cites W3010846908 @default.
- W4313305828 cites W3017015673 @default.
- W4313305828 cites W3047104964 @default.
- W4313305828 cites W3047740470 @default.
- W4313305828 cites W3129493227 @default.
- W4313305828 cites W3134320655 @default.
- W4313305828 cites W4248109479 @default.
- W4313305828 doi "https://doi.org/10.1097/cm9.0000000000002323" @default.
- W4313305828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36583863" @default.
- W4313305828 hasPublicationYear "2022" @default.
- W4313305828 type Work @default.
- W4313305828 citedByCount "0" @default.
- W4313305828 crossrefType "journal-article" @default.
- W4313305828 hasAuthorship W4313305828A5000821582 @default.
- W4313305828 hasAuthorship W4313305828A5003554962 @default.
- W4313305828 hasAuthorship W4313305828A5004003643 @default.
- W4313305828 hasAuthorship W4313305828A5048725712 @default.
- W4313305828 hasAuthorship W4313305828A5060239423 @default.
- W4313305828 hasAuthorship W4313305828A5067876890 @default.
- W4313305828 hasAuthorship W4313305828A5074586582 @default.
- W4313305828 hasBestOaLocation W43133058281 @default.
- W4313305828 hasConcept C104317684 @default.
- W4313305828 hasConcept C1491633281 @default.
- W4313305828 hasConcept C150194340 @default.
- W4313305828 hasConcept C152724338 @default.
- W4313305828 hasConcept C162317418 @default.
- W4313305828 hasConcept C177504595 @default.
- W4313305828 hasConcept C189014844 @default.
- W4313305828 hasConcept C2777074287 @default.
- W4313305828 hasConcept C54355233 @default.
- W4313305828 hasConcept C81885089 @default.
- W4313305828 hasConcept C86339819 @default.
- W4313305828 hasConcept C86803240 @default.
- W4313305828 hasConcept C95444343 @default.
- W4313305828 hasConceptScore W4313305828C104317684 @default.
- W4313305828 hasConceptScore W4313305828C1491633281 @default.
- W4313305828 hasConceptScore W4313305828C150194340 @default.
- W4313305828 hasConceptScore W4313305828C152724338 @default.
- W4313305828 hasConceptScore W4313305828C162317418 @default.
- W4313305828 hasConceptScore W4313305828C177504595 @default.
- W4313305828 hasConceptScore W4313305828C189014844 @default.
- W4313305828 hasConceptScore W4313305828C2777074287 @default.
- W4313305828 hasConceptScore W4313305828C54355233 @default.
- W4313305828 hasConceptScore W4313305828C81885089 @default.
- W4313305828 hasConceptScore W4313305828C86339819 @default.
- W4313305828 hasConceptScore W4313305828C86803240 @default.
- W4313305828 hasConceptScore W4313305828C95444343 @default.
- W4313305828 hasIssue "20" @default.
- W4313305828 hasLocation W43133058281 @default.
- W4313305828 hasLocation W43133058282 @default.
- W4313305828 hasLocation W43133058283 @default.
- W4313305828 hasLocation W43133058284 @default.
- W4313305828 hasOpenAccess W4313305828 @default.
- W4313305828 hasPrimaryLocation W43133058281 @default.
- W4313305828 hasRelatedWork W1972690592 @default.
- W4313305828 hasRelatedWork W2509567726 @default.
- W4313305828 hasRelatedWork W2567593964 @default.
- W4313305828 hasRelatedWork W2747721337 @default.
- W4313305828 hasRelatedWork W2897350575 @default.
- W4313305828 hasRelatedWork W2973586877 @default.
- W4313305828 hasRelatedWork W3025961873 @default.
- W4313305828 hasRelatedWork W3153252782 @default.
- W4313305828 hasRelatedWork W3157307916 @default.
- W4313305828 hasRelatedWork W4327953406 @default.
- W4313305828 hasVolume "135" @default.
- W4313305828 isParatext "false" @default.
- W4313305828 isRetracted "false" @default.
- W4313305828 workType "article" @default.