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- W4313305840 endingPage "2426" @default.
- W4313305840 startingPage "2417" @default.
- W4313305840 abstract "Abstract Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which are characterized by excessive inflammation and accompanied by diffuse injury of alveoli, can result in severe respiratory failures. The morbidity and mortality of patients remain high because the major treatments for ALI/ARDS are mainly supportive due to the lack of effective therapies. Numerous studies have demonstrated that the aggravation of coronavirus disease 2019 (COVID-19) leads to severe pneumonia and even ARDS. Pyroptosis, a biological process identified as a type of programed cell death, is mainly triggered by inflammatory caspase activation and is directly meditated by the gasdermin protein family, as well as being associated with the secretion and release of pro-inflammatory cytokines. Clinical and experimental evidence corroborates that pyroptosis of various cells in the lung, such as immune cells and structural cells, may play an important role in the pathogenesis of “cytokine storms” in ALI/ARDS, including those induced by COVID-19. Here, with a focus on ALI/ARDS and COVID-19, we summarized the recent advances in this field and proposed the theory of an inflammatory cascade in pyroptosis to identify new targets and pave the way for new approaches to treat these diseases." @default.
- W4313305840 created "2023-01-06" @default.
- W4313305840 creator A5035348100 @default.
- W4313305840 creator A5041951758 @default.
- W4313305840 creator A5063163553 @default.
- W4313305840 date "2022-10-20" @default.
- W4313305840 modified "2023-10-01" @default.
- W4313305840 title "Molecular mechanisms and roles of pyroptosis in acute lung injury" @default.
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