Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313305889> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4313305889 endingPage "114.8" @default.
- W4313305889 startingPage "114.8" @default.
- W4313305889 abstract "Abstract Pbx1 controls chromatin accessibility to a large number of genes. Pbx1-d is a Pbx1 dominant negative isoform lacking the DNA binding domain, and its expression is more frequent in the CD4+ T cells from lupus patients than in healthy controls. Pbx1-d is associated with the production of autoreactive CD4+ T cells in the Sle1a1 lupus susceptibility locus and lupus susceptibility in the B6.Sle1.Sle2.Sle3 mouse model. We have generated Pbx1-d Tg mice that specifically express Pbx1-d in CD4+ T cells. These Tg mice reproduce the phenotypes of Sle1a1 mice, with increased inflammatory functions of CD4+ T cells and impaired regulatory T (Treg) cell homeostasis. Pbx1-d Tg mice also present an increased number of follicular helper T (TFH) cells, which expand with age in naïve mice, and result in enhanced TH1-biased antibody production in response to T-dependent immunization. Interestingly, the relative distribution of TFH and regulatory T (TFR) cell populations is different in both Pbx1-d Tg and Sle1a1 mice as compared with wild-type mice. Adoptive transfers of OT-II.Pbx1-d Tg CD4+ T cells showed that Pbx1-d overexpression expands TFH cell differentiation in a cell-intrinsic and antigen-specific manner. Our results suggest that Pbx1-d impacts lupus development by regulating effector T cell differentiation by promoting TFH to the expense of Treg cell. In addition, our results identify Pbx1-d as a novel regulator of CD4+ T cell effector function." @default.
- W4313305889 created "2023-01-06" @default.
- W4313305889 creator A5002019326 @default.
- W4313305889 creator A5076397278 @default.
- W4313305889 date "2015-05-01" @default.
- W4313305889 modified "2023-09-25" @default.
- W4313305889 title "Overexpression of Pbx1-d, a novel splice isoform of Pbx1, in CD4+ T cells promotes follicular helper T cell differentiation (BA6P.127)" @default.
- W4313305889 doi "https://doi.org/10.4049/jimmunol.194.supp.114.8" @default.
- W4313305889 hasPublicationYear "2015" @default.
- W4313305889 type Work @default.
- W4313305889 citedByCount "0" @default.
- W4313305889 crossrefType "journal-article" @default.
- W4313305889 hasAuthorship W4313305889A5002019326 @default.
- W4313305889 hasAuthorship W4313305889A5076397278 @default.
- W4313305889 hasConcept C104317684 @default.
- W4313305889 hasConcept C129374314 @default.
- W4313305889 hasConcept C148738053 @default.
- W4313305889 hasConcept C153911025 @default.
- W4313305889 hasConcept C159654299 @default.
- W4313305889 hasConcept C203014093 @default.
- W4313305889 hasConcept C2776090121 @default.
- W4313305889 hasConcept C2780130043 @default.
- W4313305889 hasConcept C54355233 @default.
- W4313305889 hasConcept C86803240 @default.
- W4313305889 hasConcept C8891405 @default.
- W4313305889 hasConcept C90375314 @default.
- W4313305889 hasConcept C95444343 @default.
- W4313305889 hasConceptScore W4313305889C104317684 @default.
- W4313305889 hasConceptScore W4313305889C129374314 @default.
- W4313305889 hasConceptScore W4313305889C148738053 @default.
- W4313305889 hasConceptScore W4313305889C153911025 @default.
- W4313305889 hasConceptScore W4313305889C159654299 @default.
- W4313305889 hasConceptScore W4313305889C203014093 @default.
- W4313305889 hasConceptScore W4313305889C2776090121 @default.
- W4313305889 hasConceptScore W4313305889C2780130043 @default.
- W4313305889 hasConceptScore W4313305889C54355233 @default.
- W4313305889 hasConceptScore W4313305889C86803240 @default.
- W4313305889 hasConceptScore W4313305889C8891405 @default.
- W4313305889 hasConceptScore W4313305889C90375314 @default.
- W4313305889 hasConceptScore W4313305889C95444343 @default.
- W4313305889 hasIssue "1_Supplement" @default.
- W4313305889 hasLocation W43133058891 @default.
- W4313305889 hasOpenAccess W4313305889 @default.
- W4313305889 hasPrimaryLocation W43133058891 @default.
- W4313305889 hasRelatedWork W1971278368 @default.
- W4313305889 hasRelatedWork W1989702918 @default.
- W4313305889 hasRelatedWork W1995461993 @default.
- W4313305889 hasRelatedWork W2000442621 @default.
- W4313305889 hasRelatedWork W2050032228 @default.
- W4313305889 hasRelatedWork W2165678561 @default.
- W4313305889 hasRelatedWork W2262741309 @default.
- W4313305889 hasRelatedWork W2465512521 @default.
- W4313305889 hasRelatedWork W2770663599 @default.
- W4313305889 hasRelatedWork W3169398005 @default.
- W4313305889 hasVolume "194" @default.
- W4313305889 isParatext "false" @default.
- W4313305889 isRetracted "false" @default.
- W4313305889 workType "article" @default.