Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313305895> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4313305895 endingPage "115.7" @default.
- W4313305895 startingPage "115.7" @default.
- W4313305895 abstract "Abstract Several mouse models of SLE, including FcgRIIB-KO and TLR7tg mice, develop an expansion of an atypical NK cell subset with functional similarity to cells referred as IKDCs or pre-mNKs in other systems and identified as NK1.1+CD11c+CD122+MHC-II+. These cells belong to the NK cell lineage because they depend on IL15 and express E4BP4. Functionally they are cytotoxic, produce type I and type II interferons upon activation and they are efficient antigen presenting cells both through MHC-II expression and in cross-presentation to CD8s. These atypical NK cells are responsive to TLR stimulation and thus are most abundant in mice with high copy number of the Tlr7 gene. They are highly proliferative as assessed by in vivo BrdU incorporation. Transferring 4 million atypical NKs purified from spleens of SLE-prone mice into WT induces a 2-week-long wave of inflammatory cytokines in the serum, a sustained increase in T cell activation and follicular helper cells for the following months, and a progressive expansion of dendritic cells, monocytes and granulocytes. Furthermore IL15 deficiency, which impedes development of NK cells, ameliorates the autoimmune pathology of TLR7tg mice. These results suggest that cells of the NK lineage can develop into cytokine producing/antigen-presenting cells that affect the priming and progression of systemic autoimmune disease." @default.
- W4313305895 created "2023-01-06" @default.
- W4313305895 creator A5007037322 @default.
- W4313305895 creator A5016713616 @default.
- W4313305895 creator A5052612176 @default.
- W4313305895 creator A5081166792 @default.
- W4313305895 creator A5088731604 @default.
- W4313305895 date "2015-05-01" @default.
- W4313305895 modified "2023-09-26" @default.
- W4313305895 title "Induction of autoimmune disease by adoptive transfer of an atypical NK cell subset (BA7P.147)" @default.
- W4313305895 doi "https://doi.org/10.4049/jimmunol.194.supp.115.7" @default.
- W4313305895 hasPublicationYear "2015" @default.
- W4313305895 type Work @default.
- W4313305895 citedByCount "0" @default.
- W4313305895 crossrefType "journal-article" @default.
- W4313305895 hasAuthorship W4313305895A5007037322 @default.
- W4313305895 hasAuthorship W4313305895A5016713616 @default.
- W4313305895 hasAuthorship W4313305895A5052612176 @default.
- W4313305895 hasAuthorship W4313305895A5081166792 @default.
- W4313305895 hasAuthorship W4313305895A5088731604 @default.
- W4313305895 hasConcept C100701293 @default.
- W4313305895 hasConcept C104317684 @default.
- W4313305895 hasConcept C127716648 @default.
- W4313305895 hasConcept C129374314 @default.
- W4313305895 hasConcept C147483822 @default.
- W4313305895 hasConcept C149532602 @default.
- W4313305895 hasConcept C154317977 @default.
- W4313305895 hasConcept C167672396 @default.
- W4313305895 hasConcept C183315844 @default.
- W4313305895 hasConcept C202751555 @default.
- W4313305895 hasConcept C203014093 @default.
- W4313305895 hasConcept C2776090121 @default.
- W4313305895 hasConcept C2778690821 @default.
- W4313305895 hasConcept C2779919695 @default.
- W4313305895 hasConcept C3753494 @default.
- W4313305895 hasConcept C55493867 @default.
- W4313305895 hasConcept C59822182 @default.
- W4313305895 hasConcept C67662055 @default.
- W4313305895 hasConcept C74172505 @default.
- W4313305895 hasConcept C81444415 @default.
- W4313305895 hasConcept C83464605 @default.
- W4313305895 hasConcept C86803240 @default.
- W4313305895 hasConcept C8891405 @default.
- W4313305895 hasConcept C90375314 @default.
- W4313305895 hasConcept C98119934 @default.
- W4313305895 hasConceptScore W4313305895C100701293 @default.
- W4313305895 hasConceptScore W4313305895C104317684 @default.
- W4313305895 hasConceptScore W4313305895C127716648 @default.
- W4313305895 hasConceptScore W4313305895C129374314 @default.
- W4313305895 hasConceptScore W4313305895C147483822 @default.
- W4313305895 hasConceptScore W4313305895C149532602 @default.
- W4313305895 hasConceptScore W4313305895C154317977 @default.
- W4313305895 hasConceptScore W4313305895C167672396 @default.
- W4313305895 hasConceptScore W4313305895C183315844 @default.
- W4313305895 hasConceptScore W4313305895C202751555 @default.
- W4313305895 hasConceptScore W4313305895C203014093 @default.
- W4313305895 hasConceptScore W4313305895C2776090121 @default.
- W4313305895 hasConceptScore W4313305895C2778690821 @default.
- W4313305895 hasConceptScore W4313305895C2779919695 @default.
- W4313305895 hasConceptScore W4313305895C3753494 @default.
- W4313305895 hasConceptScore W4313305895C55493867 @default.
- W4313305895 hasConceptScore W4313305895C59822182 @default.
- W4313305895 hasConceptScore W4313305895C67662055 @default.
- W4313305895 hasConceptScore W4313305895C74172505 @default.
- W4313305895 hasConceptScore W4313305895C81444415 @default.
- W4313305895 hasConceptScore W4313305895C83464605 @default.
- W4313305895 hasConceptScore W4313305895C86803240 @default.
- W4313305895 hasConceptScore W4313305895C8891405 @default.
- W4313305895 hasConceptScore W4313305895C90375314 @default.
- W4313305895 hasConceptScore W4313305895C98119934 @default.
- W4313305895 hasIssue "1_Supplement" @default.
- W4313305895 hasLocation W43133058951 @default.
- W4313305895 hasOpenAccess W4313305895 @default.
- W4313305895 hasPrimaryLocation W43133058951 @default.
- W4313305895 hasRelatedWork W1533866843 @default.
- W4313305895 hasRelatedWork W1566867317 @default.
- W4313305895 hasRelatedWork W1618908972 @default.
- W4313305895 hasRelatedWork W1970684135 @default.
- W4313305895 hasRelatedWork W198401270 @default.
- W4313305895 hasRelatedWork W2008057646 @default.
- W4313305895 hasRelatedWork W2073250710 @default.
- W4313305895 hasRelatedWork W2105429571 @default.
- W4313305895 hasRelatedWork W2156937928 @default.
- W4313305895 hasRelatedWork W4313305895 @default.
- W4313305895 hasVolume "194" @default.
- W4313305895 isParatext "false" @default.
- W4313305895 isRetracted "false" @default.
- W4313305895 workType "article" @default.