Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313305898> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4313305898 endingPage "120.12" @default.
- W4313305898 startingPage "120.12" @default.
- W4313305898 abstract "Abstract During steady-state hematopoiesis, the monocytic lineage, which includes macrophages, osteoclasts, monocytes, and monocyte-derived dendritic cells (moDCs), arises from a progenitor hierarchy in bone marrow. In humans, multipotent myeloid progenitors such as the granulocyte-monocyte progenitor (GMP) are proximal in this hierarchy, however the distal stages of monocytopoieis are unclear. We report here identification of a human clonogenic, monocytic-committed progenitor with a lineage negative, CD34+ CD38+ CD45RA+ CD123int CD115+ phenotype, which was developmentally conserved across bone marrow, cord blood, and fetal liver. Ex vivo analysis demonstrated a high cloning efficiency, and monocytic but not granulocytic CFU potential. Differentiation in the presence of M-CSF resulted in exclusive production of functional M2-like macrophages, whereas cultures modified with RANKL and GM-CSF/IL-4 resulted in highly enriched cultures of functional osteoclasts and moDCs, respectively. Transplantation into immunodeficient mice reconstituted bone marrow, splenic, pulmonary, and hepatic macrophage subsets, as well as circulating CD14+ monocytic cells. Of note, GMP depleted of CD115+ cells could regenerate the monocytic progenitor phenotype in vitro and in vivo, consistent with a step-wise program of lineage restriction during monocytopoiesis. Identification of the steady-state human monocytic progenitor offers opportunities for therapeutic expansion or modification of the monocytic lineage." @default.
- W4313305898 created "2023-01-06" @default.
- W4313305898 creator A5039124941 @default.
- W4313305898 creator A5040485370 @default.
- W4313305898 creator A5061114123 @default.
- W4313305898 creator A5063403085 @default.
- W4313305898 creator A5065141793 @default.
- W4313305898 creator A5068956158 @default.
- W4313305898 creator A5085643102 @default.
- W4313305898 date "2015-05-01" @default.
- W4313305898 modified "2023-09-28" @default.
- W4313305898 title "Identification of a human clonogenic monocyte/macrophage progenitor in fetal and adult hematopoiesis (HEM5P.232)" @default.
- W4313305898 doi "https://doi.org/10.4049/jimmunol.194.supp.120.12" @default.
- W4313305898 hasPublicationYear "2015" @default.
- W4313305898 type Work @default.
- W4313305898 citedByCount "0" @default.
- W4313305898 crossrefType "journal-article" @default.
- W4313305898 hasAuthorship W4313305898A5039124941 @default.
- W4313305898 hasAuthorship W4313305898A5040485370 @default.
- W4313305898 hasAuthorship W4313305898A5061114123 @default.
- W4313305898 hasAuthorship W4313305898A5063403085 @default.
- W4313305898 hasAuthorship W4313305898A5065141793 @default.
- W4313305898 hasAuthorship W4313305898A5068956158 @default.
- W4313305898 hasAuthorship W4313305898A5085643102 @default.
- W4313305898 hasConcept C109159458 @default.
- W4313305898 hasConcept C201750760 @default.
- W4313305898 hasConcept C203014093 @default.
- W4313305898 hasConcept C2779282312 @default.
- W4313305898 hasConcept C2780007613 @default.
- W4313305898 hasConcept C2781184567 @default.
- W4313305898 hasConcept C28328180 @default.
- W4313305898 hasConcept C86803240 @default.
- W4313305898 hasConcept C95444343 @default.
- W4313305898 hasConceptScore W4313305898C109159458 @default.
- W4313305898 hasConceptScore W4313305898C201750760 @default.
- W4313305898 hasConceptScore W4313305898C203014093 @default.
- W4313305898 hasConceptScore W4313305898C2779282312 @default.
- W4313305898 hasConceptScore W4313305898C2780007613 @default.
- W4313305898 hasConceptScore W4313305898C2781184567 @default.
- W4313305898 hasConceptScore W4313305898C28328180 @default.
- W4313305898 hasConceptScore W4313305898C86803240 @default.
- W4313305898 hasConceptScore W4313305898C95444343 @default.
- W4313305898 hasIssue "1_Supplement" @default.
- W4313305898 hasLocation W43133058981 @default.
- W4313305898 hasOpenAccess W4313305898 @default.
- W4313305898 hasPrimaryLocation W43133058981 @default.
- W4313305898 hasRelatedWork W1977841877 @default.
- W4313305898 hasRelatedWork W2011495040 @default.
- W4313305898 hasRelatedWork W2017802236 @default.
- W4313305898 hasRelatedWork W2027927113 @default.
- W4313305898 hasRelatedWork W2076188533 @default.
- W4313305898 hasRelatedWork W2148465260 @default.
- W4313305898 hasRelatedWork W2564717365 @default.
- W4313305898 hasRelatedWork W3029982150 @default.
- W4313305898 hasRelatedWork W3166197489 @default.
- W4313305898 hasRelatedWork W1968377433 @default.
- W4313305898 hasVolume "194" @default.
- W4313305898 isParatext "false" @default.
- W4313305898 isRetracted "false" @default.
- W4313305898 workType "article" @default.