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- W4313305903 abstract "Abstract Regulatory T cells (Tr cells) are potent anti-inflammatory cells that restrain autoimmune and inflammatory disease by dampening immune responses to self- and foreign-antigens. Given their potent immunosuppressive properties, manipulation of the Tr cell compartment is an attractive therapeutic strategy to either boost or inhibit immune responses in a variety of clinical settings. Proper implementation of Tr cell based immunotherapies necessitates a clearer understanding of how these cells are maintained in different anatomical niches under homeostatic conditions. Although it has been recognized for several years that dendritic cells (DC) help control Tr cell abundance and function, the mechanisms of this cross-talk, and a more specific definition of the cellular and molecular components underlying Tr cell maintenance by DCs, has not been elucidated. Here we show Il-2 signaling in Tr cells, which is critical for their proper homeostasis and function, is DC dependent. Intriguingly, CD8α+ DCs are not required for Il-2 activation in Tr cells and their frequencies are in fact elevated in BATf3-/- mice lacking CD8α+ DCs. Instead 33D1+ DCs have a critical yet indirect function in the generation of Tr cell supportive Il-2, and this effect is largely mediated by the micro-anatomical positioning of these cells within T cell zones of secondary lymphoid organs." @default.
- W4313305903 created "2023-01-06" @default.
- W4313305903 creator A5015081209 @default.
- W4313305903 date "2015-05-01" @default.
- W4313305903 modified "2023-09-25" @default.
- W4313305903 title "33D1+ dendritic cells in the maintenance of Il-2 dependent regulatory T cells (BA6P.130)" @default.
- W4313305903 doi "https://doi.org/10.4049/jimmunol.194.supp.114.11" @default.
- W4313305903 hasPublicationYear "2015" @default.
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