FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313305932> ?p ?o ?g. }

• W4313305932 endingPage "6613" @default.
• W4313305932 startingPage "6604" @default.
• W4313305932 abstract "Abstract T cell hybridomas HCQ6 and MD.45 acquired Ab-type specificity to collagen type II, when engrafted with a chimeric cell surface receptor, scC2Fv/γ, which includes the single-chain Fv domain (scFv) of the anti-collagen type II mAb C2 and the signaling γ subunit of the FcεRI. When transduced into MD.45 cells, scC2Fv/γ or its mutated form lacking immunoreceptor tyrosine-based activation motif (ITAM), scC2Fv/γIC−, formed mainly homodimers. A small proportion of these molecules formed heterodimers with endogenous CD3ζ in these hybridoma cells. By contrast, in HCQ6 cells, the majority of scC2Fv/γ and scC2Fv/γIC− molecules formed heterodimers with CD3ζ, and only a small proportion of them was expressed as homodimers. Stimulation with plastic-immobilized collagen induced IL-2 production in scC2Fv/γ-transduced MD.45 cells, but not in MD.45 cells transduced with the ITAM-less chimera scC2Fv/γIC−. HCQ6 cells transduced with scC2Fv/γ responded to plastic-bound collagen. Due to the high content of CD3ζ-associated chimeras, HCQ6 cells transduced with the ITAM-less scC2Fv/γIC− chimera were also responsive to plastic-bound collagen. When cells were stimulated with collagen in solution, MD.45 cells transduced with scC2Fv/γ produced IL-2, whereas transduced HCQ6 cells were unresponsive, hence suggesting that the ability of cells transduced with scC2Fv chimeras to respond to soluble collagen correlated with predominant expression of divalent scC2Fv/γ homodimers, but not monovalent scC2Fv/γ-CD3ζ or scC2Fv/γIC−-CD3ζ heterodimers. Of interest, expression of CD3 subunits in hybridomas transduced with scC2Fv chimeras was reduced, resulting in decreased response to cognate Ags." @default.
• W4313305932 created "2023-01-06" @default.
• W4313305932 creator A5006512036 @default.
• W4313305932 creator A5055773624 @default.
• W4313305932 creator A5062040075 @default.
• W4313305932 creator A5067923997 @default.
• W4313305932 creator A5077515411 @default.
• W4313305932 date "1998-12-15" @default.
• W4313305932 modified "2023-09-30" @default.
• W4313305932 title "Loss of Original Antigenic Specificity in T Cell Hybridomas Transduced with a Chimeric Receptor Containing Single-Chain Fv of an Anti-Collagen Antibody and FcεRI-Signaling γ Subunit" @default.
• W4313305932 cites W1480169020 @default.
• W4313305932 cites W1494561978 @default.
• W4313305932 cites W1547497180 @default.
• W4313305932 cites W1583452133 @default.
• W4313305932 cites W1750539994 @default.
• W4313305932 cites W1870676208 @default.
• W4313305932 cites W1914553247 @default.
• W4313305932 cites W1974994250 @default.
• W4313305932 cites W1975957996 @default.
• W4313305932 cites W1982425773 @default.
• W4313305932 cites W1985493411 @default.
• W4313305932 cites W1988312926 @default.
• W4313305932 cites W2006659499 @default.
• W4313305932 cites W2019570600 @default.
• W4313305932 cites W2028460943 @default.
• W4313305932 cites W2033838615 @default.
• W4313305932 cites W2036540579 @default.
• W4313305932 cites W2039042143 @default.
• W4313305932 cites W2042582068 @default.
• W4313305932 cites W2044336492 @default.
• W4313305932 cites W2044885674 @default.
• W4313305932 cites W2047205338 @default.
• W4313305932 cites W2047506077 @default.
• W4313305932 cites W2054851985 @default.
• W4313305932 cites W2069028742 @default.
• W4313305932 cites W2079837731 @default.
• W4313305932 cites W2080476991 @default.
• W4313305932 cites W2080966713 @default.
• W4313305932 cites W2132069692 @default.
• W4313305932 cites W2136847875 @default.
• W4313305932 cites W2181083086 @default.
• W4313305932 cites W2470768411 @default.
• W4313305932 cites W4294216491 @default.
• W4313305932 cites W78775163 @default.
• W4313305932 doi "https://doi.org/10.4049/jimmunol.161.12.6604" @default.
• W4313305932 hasPublicationYear "1998" @default.
• W4313305932 type Work @default.
• W4313305932 citedByCount "12" @default.
• W4313305932 countsByYear W43133059322015 @default.
• W4313305932 countsByYear W43133059322016 @default.
• W4313305932 countsByYear W43133059322017 @default.
• W4313305932 countsByYear W43133059322022 @default.
• W4313305932 crossrefType "journal-article" @default.
• W4313305932 hasAuthorship W4313305932A5006512036 @default.
• W4313305932 hasAuthorship W4313305932A5055773624 @default.
• W4313305932 hasAuthorship W4313305932A5062040075 @default.
• W4313305932 hasAuthorship W4313305932A5067923997 @default.
• W4313305932 hasAuthorship W4313305932A5077515411 @default.
• W4313305932 hasConcept C104292427 @default.
• W4313305932 hasConcept C104317684 @default.
• W4313305932 hasConcept C114684123 @default.
• W4313305932 hasConcept C147483822 @default.
• W4313305932 hasConcept C153911025 @default.
• W4313305932 hasConcept C159654299 @default.
• W4313305932 hasConcept C167672396 @default.
• W4313305932 hasConcept C185592680 @default.
• W4313305932 hasConcept C19317047 @default.
• W4313305932 hasConcept C195616568 @default.
• W4313305932 hasConcept C203014093 @default.
• W4313305932 hasConcept C2776090121 @default.
• W4313305932 hasConcept C30278631 @default.
• W4313305932 hasConcept C55493867 @default.
• W4313305932 hasConcept C86803240 @default.
• W4313305932 hasConcept C8891405 @default.
• W4313305932 hasConcept C95444343 @default.
• W4313305932 hasConceptScore W4313305932C104292427 @default.
• W4313305932 hasConceptScore W4313305932C104317684 @default.
• W4313305932 hasConceptScore W4313305932C114684123 @default.
• W4313305932 hasConceptScore W4313305932C147483822 @default.
• W4313305932 hasConceptScore W4313305932C153911025 @default.
• W4313305932 hasConceptScore W4313305932C159654299 @default.
• W4313305932 hasConceptScore W4313305932C167672396 @default.
• W4313305932 hasConceptScore W4313305932C185592680 @default.
• W4313305932 hasConceptScore W4313305932C19317047 @default.
• W4313305932 hasConceptScore W4313305932C195616568 @default.
• W4313305932 hasConceptScore W4313305932C203014093 @default.
• W4313305932 hasConceptScore W4313305932C2776090121 @default.
• W4313305932 hasConceptScore W4313305932C30278631 @default.
• W4313305932 hasConceptScore W4313305932C55493867 @default.
• W4313305932 hasConceptScore W4313305932C86803240 @default.
• W4313305932 hasConceptScore W4313305932C8891405 @default.
• W4313305932 hasConceptScore W4313305932C95444343 @default.
• W4313305932 hasIssue "12" @default.
• W4313305932 hasLocation W43133059321 @default.
• W4313305932 hasOpenAccess W4313305932 @default.
• W4313305932 hasPrimaryLocation W43133059321 @default.
• W4313305932 hasRelatedWork W138661586 @default.
• W4313305932 hasRelatedWork W1604248381 @default.

• next