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- W4313305937 abstract "Abstract Activation-induced death of T cells regulates immune responses and is considered to involve apoptosis induced by ligation of Fas and TNF receptors. The role of other receptors in signaling T cell death is less clear. In this study we demonstrate that activation of specific epitopes on the Ig variable domain of CD47 rapidly induces apoptosis of T cells. A new mAb, Ad22, to this site induces apoptosis of Jurkat cells and CD3ε-stimulated PBMC, as determined by morphological changes, phosphatidylserine exposure on the cell surface, uptake of propidium iodide, and true counts by flow cytometry. In contrast, apoptosis was not observed following culture with anti-CD47 mAbs 2D3 or B6H12 directed to a distant or closely adjacent region, respectively. CD47-mediated cell death was independent of CD3, CD4, CD45, or p56lck involvement as demonstrated by studies with variant Jurkat cell lines deficient in these signaling pathways. However, coligation of CD3ε and CD47 enhanced phosphatidylserine externalization on Jurkat cells with functional CD3. Furthermore, normal T cells required preactivation to respond with CD47-induced apoptosis. CD47-mediated cell death appeared to proceed independent of Fas or TNF receptor signaling and did not involve characteristic DNA fragmentation or requirement for IL-1β-converting enzyme-like proteases or CPP32. Taken together, our data demonstrate that under appropriate conditions, CD47 activation results in very rapid T cell death, apparently mediated by a novel apoptotic pathway. Thus, CD47 may be critically involved in controlling the fate of activated T cells." @default.
- W4313305937 created "2023-01-06" @default.
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- W4313305937 date "1999-06-15" @default.
- W4313305937 modified "2023-10-10" @default.
- W4313305937 title "CD47 Signals T Cell Death" @default.
- W4313305937 cites W1490870966 @default.
- W4313305937 cites W1503346435 @default.
- W4313305937 cites W1509098294 @default.
- W4313305937 cites W1531973880 @default.
- W4313305937 cites W1534774246 @default.
- W4313305937 cites W1562057469 @default.
- W4313305937 cites W1568149599 @default.
- W4313305937 cites W1571897256 @default.
- W4313305937 cites W1583749010 @default.
- W4313305937 cites W1584666781 @default.
- W4313305937 cites W1594989289 @default.
- W4313305937 cites W1672583226 @default.
- W4313305937 cites W1672677573 @default.
- W4313305937 cites W1753064097 @default.
- W4313305937 cites W1901122018 @default.
- W4313305937 cites W1915589840 @default.
- W4313305937 cites W1950362618 @default.
- W4313305937 cites W1966607669 @default.
- W4313305937 cites W1968519328 @default.
- W4313305937 cites W1971063170 @default.
- W4313305937 cites W1980024819 @default.
- W4313305937 cites W1989914829 @default.
- W4313305937 cites W1990917512 @default.
- W4313305937 cites W1994688157 @default.
- W4313305937 cites W1999747291 @default.
- W4313305937 cites W2002131156 @default.
- W4313305937 cites W2003285575 @default.
- W4313305937 cites W2004281734 @default.
- W4313305937 cites W2012681367 @default.
- W4313305937 cites W2015085911 @default.
- W4313305937 cites W2017185316 @default.
- W4313305937 cites W2018495204 @default.
- W4313305937 cites W2023809975 @default.
- W4313305937 cites W2028111124 @default.
- W4313305937 cites W2028890259 @default.
- W4313305937 cites W2032289653 @default.
- W4313305937 cites W2034740640 @default.
- W4313305937 cites W2037626742 @default.
- W4313305937 cites W2044907066 @default.
- W4313305937 cites W2048073154 @default.
- W4313305937 cites W2053620210 @default.
- W4313305937 cites W2062718933 @default.
- W4313305937 cites W2063989887 @default.
- W4313305937 cites W2065413461 @default.
- W4313305937 cites W2068089627 @default.
- W4313305937 cites W2074932405 @default.
- W4313305937 cites W2086375193 @default.
- W4313305937 cites W2090481553 @default.
- W4313305937 cites W2092167776 @default.
- W4313305937 cites W2093392246 @default.
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- W4313305937 cites W2113393768 @default.
- W4313305937 cites W2122832461 @default.
- W4313305937 cites W2123642439 @default.
- W4313305937 cites W2129971278 @default.
- W4313305937 cites W2133725847 @default.
- W4313305937 cites W2134352843 @default.
- W4313305937 cites W2143188779 @default.
- W4313305937 cites W2144017515 @default.
- W4313305937 cites W2144267004 @default.
- W4313305937 cites W2144485902 @default.
- W4313305937 cites W2144935474 @default.
- W4313305937 cites W2145740810 @default.
- W4313305937 cites W2146907765 @default.
- W4313305937 cites W2150087633 @default.
- W4313305937 cites W2154055388 @default.
- W4313305937 cites W2162856391 @default.
- W4313305937 cites W2166291746 @default.
- W4313305937 cites W2168324886 @default.
- W4313305937 cites W2258639618 @default.
- W4313305937 cites W2297826429 @default.
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- W4313305937 doi "https://doi.org/10.4049/jimmunol.162.12.7031" @default.
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