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• W4313305942 abstract "Summary Four sheep injected with HGBM and Freund's adjuvant and one injected with RGBM and Freund's adjuvant developed fulminating glomerulonephritis, presumably by an autoimmune mechanism. Four controls injected with Freund's adjuvant alone did not develop nephritis. Sera taken from all five sheep with terminal nephritis were injected into rabbits intravenously and produced acute diffuse proliferative and exudative glomerulonephritis. The nephritis induced in rabbits by sheep anti-HGBM or anti-RGBM sera was immediate in onset or delayed in onset (5 to 11 days). The onset of the nephritis was correlated with the dosage of antisera administered. In this experiment the amount of cross-reacting sheep anti-HGBM sera needed to produce immediate nephritis was 20 to 60 times greater than the amount of sheep anti-RGBM serum required. Human GBM contains at least two different nephrotoxic antigens: one is closely related to a nephrotoxic antigen(s) in rabbit GBM. The other is presumably not present in rabbit GBM, but is closely related to an antigen(s) in dog GBM. Delayed nephrotoxic serum nephritis was differentiated from serum sickness nephritis by such characteristics of proteinuria as onset, amount and duration. The histopathology of the two kinds of nephritis was different and distinctive. A two-stage mechanism for nephrotoxic serum nephritis was presented. The first stage consists of immediate localization of nephrotoxic antibodies on glomerular basement membrane. If the ratio of injected antibodies per glomerulus reaches a certain critical level, detectable proteinuria and glomerular damage appear immediately after injection. The second stage consists of formation of antibodies against the injected γ-globulin and reaction of these antibodies with the localized antibodies in the glomerulus. Some rabbits may have a superimposed serum sickness due to the various kinds of circulating sheep serum antigen-rabbit antibody complexes. Although serum sickness and the second stage delayed nephrotoxic serum nephritis both depend on host antibodies to initiate their different mechanisms of glomerular damage, proteinuria began significantly earlier in the delayed nephrotoxic nephritis group. This may be due to the prior localization of nephrotoxic antibody in the glomerulus and/or subclinical first stage glomerular damage. Production of nephritis in rabbits with sera from sheep dying of nephritis induced by active immunization is the first example that we are aware of where the species producing the nephrotoxic antibodies developed nephritis itself: the relationship of the nephrotoxic antibodies demonstrated against the rabbit glomerulus with the pathogenesis of the sheep disease is not clear." @default.
• W4313305942 created "2023-01-06" @default.
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• W4313305942 date "1965-09-01" @default.
• W4313305942 modified "2023-09-27" @default.
• W4313305942 title "Some Immunologic Properties of Human Glomerular Basement Membrane" @default.
• W4313305942 doi "https://doi.org/10.4049/jimmunol.95.3.517" @default.
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