Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313305945> ?p ?o ?g. }
- W4313305945 endingPage "6760" @default.
- W4313305945 startingPage "6751" @default.
- W4313305945 abstract "Abstract TGF-β1 directs class switching to IgA by splenic B cells and by the surface IgM+ B cell line, I.29μ, by inducing germline (GL) Ig α transcripts. The promoter segment between −130 and +46, relative to the first initiation site for mouse GL α transcripts, is sufficient for expression and TGF-β1 inducibility of a reporter gene in B cell lines. Within this segment resides a TGF-β1-responsive element (TβRE) that is required for induction of the promoter by TGF-β1 and, when multimerized, is sufficient to transfer TGF-β1 inducibility to another promoter. In this report we show that a TGF-β1-inducible complex binds the TβRE and contains the transcription factor core-binding factor (CBF; also known as acute myeloid leukemia, AML). Although all three CBFα family members activate the GL α promoter, only CBFα3 (AML-2) is induced by TGF-β1 in splenic B and I.29μ cells. The TβRE contains two CBF binding sites. Mutation of both sites reduces but does not eliminate induction of the GL α promoter by TGF-β1 or by overexpression of CBF, possibly due to the presence of an additional CBF site in the promoter. In addition, the TβRE contains two copies of another sequence motif. Mutation of these motifs eliminates TGF-β1 induction of the GL α promoter. Together the data indicate that TGF-β1 induction of the α promoter involves induction of CBFα3, which binds to the TβRE of the promoter along with one or more proteins." @default.
- W4313305945 created "2023-01-06" @default.
- W4313305945 creator A5026011921 @default.
- W4313305945 creator A5052519786 @default.
- W4313305945 date "1998-12-15" @default.
- W4313305945 modified "2023-10-16" @default.
- W4313305945 title "CBFα3 (AML2) Is Induced by TGF-β1 to Bind and Activate the Mouse Germline Ig α Promoter" @default.
- W4313305945 cites W107818682 @default.
- W4313305945 cites W1489573122 @default.
- W4313305945 cites W1493816460 @default.
- W4313305945 cites W1495338298 @default.
- W4313305945 cites W1500700097 @default.
- W4313305945 cites W1543126301 @default.
- W4313305945 cites W1582801882 @default.
- W4313305945 cites W1602751534 @default.
- W4313305945 cites W1663371441 @default.
- W4313305945 cites W1931376925 @default.
- W4313305945 cites W1957426726 @default.
- W4313305945 cites W1982721874 @default.
- W4313305945 cites W1990974448 @default.
- W4313305945 cites W1991766825 @default.
- W4313305945 cites W1994596418 @default.
- W4313305945 cites W1997812904 @default.
- W4313305945 cites W2003617876 @default.
- W4313305945 cites W2011975744 @default.
- W4313305945 cites W2016730049 @default.
- W4313305945 cites W2019303375 @default.
- W4313305945 cites W2029827117 @default.
- W4313305945 cites W2042289154 @default.
- W4313305945 cites W2050246426 @default.
- W4313305945 cites W2055452302 @default.
- W4313305945 cites W2056560239 @default.
- W4313305945 cites W2060913542 @default.
- W4313305945 cites W2061842844 @default.
- W4313305945 cites W2065985580 @default.
- W4313305945 cites W2067961064 @default.
- W4313305945 cites W2068728784 @default.
- W4313305945 cites W2073219326 @default.
- W4313305945 cites W2074079891 @default.
- W4313305945 cites W2075027785 @default.
- W4313305945 cites W2075529268 @default.
- W4313305945 cites W2077527504 @default.
- W4313305945 cites W2077904574 @default.
- W4313305945 cites W2078460335 @default.
- W4313305945 cites W2084937656 @default.
- W4313305945 cites W2085033687 @default.
- W4313305945 cites W2086083531 @default.
- W4313305945 cites W2087406714 @default.
- W4313305945 cites W2107008702 @default.
- W4313305945 cites W2109943424 @default.
- W4313305945 cites W2113086962 @default.
- W4313305945 cites W2119973182 @default.
- W4313305945 cites W2130002948 @default.
- W4313305945 cites W2130535740 @default.
- W4313305945 cites W2137005106 @default.
- W4313305945 cites W2141947090 @default.
- W4313305945 cites W2149392416 @default.
- W4313305945 cites W2151360445 @default.
- W4313305945 cites W2157779979 @default.
- W4313305945 cites W2160931499 @default.
- W4313305945 cites W2161848417 @default.
- W4313305945 cites W2167517553 @default.
- W4313305945 cites W2167871255 @default.
- W4313305945 cites W2169522866 @default.
- W4313305945 cites W2255626223 @default.
- W4313305945 cites W4235438234 @default.
- W4313305945 cites W4243280752 @default.
- W4313305945 cites W4244915943 @default.
- W4313305945 cites W4247854464 @default.
- W4313305945 cites W4255146022 @default.
- W4313305945 cites W4313333736 @default.
- W4313305945 doi "https://doi.org/10.4049/jimmunol.161.12.6751" @default.
- W4313305945 hasPublicationYear "1998" @default.
- W4313305945 type Work @default.
- W4313305945 citedByCount "71" @default.
- W4313305945 countsByYear W43133059452012 @default.
- W4313305945 countsByYear W43133059452013 @default.
- W4313305945 countsByYear W43133059452015 @default.
- W4313305945 countsByYear W43133059452017 @default.
- W4313305945 countsByYear W43133059452018 @default.
- W4313305945 countsByYear W43133059452021 @default.
- W4313305945 countsByYear W43133059452023 @default.
- W4313305945 crossrefType "journal-article" @default.
- W4313305945 hasAuthorship W4313305945A5026011921 @default.
- W4313305945 hasAuthorship W4313305945A5052519786 @default.
- W4313305945 hasBestOaLocation W43133059451 @default.
- W4313305945 hasConcept C101762097 @default.
- W4313305945 hasConcept C104317684 @default.
- W4313305945 hasConcept C107824862 @default.
- W4313305945 hasConcept C109825262 @default.
- W4313305945 hasConcept C118131993 @default.
- W4313305945 hasConcept C138885662 @default.
- W4313305945 hasConcept C150194340 @default.
- W4313305945 hasConcept C153911025 @default.
- W4313305945 hasConcept C179926584 @default.
- W4313305945 hasConcept C2778220731 @default.
- W4313305945 hasConcept C41895202 @default.
- W4313305945 hasConcept C54355233 @default.