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- W4313305953 abstract "Abstract This study was designed to extend a recent report about the ability of hapten-primed T lymphocytes to serve as helper cells, capable of augmenting the generation of tumor-specific CTL in vivo when the priming hapten was coupled to the immunizing tumor cells. Spleen cells of mice primed with 2,4,6-trinitrophenyl-mouse γ-globulin (TNP-MGG) conjugate under conditions known to elicit hapten-reactive T lymphocytes, and subsequently immunized with TNP-derivatized, mitomycin C-treated syngeneic tumor cells, generated, upon in vitro stimulation with the relevant tumor cells, substantially higher CTL responses than did spleen cells from mice that were not primed with TNP-MGG. Furthermore, we demonstrated directly that such help resulted from T-T cell cooperation by showing that the addition of TNP-MGG-primed spleen cells in culture augmented the in vitro induction of a secondary tumorspecific CTL response upon sensitization of tumor-primed spleen cells against TNP-derivatized tumor cells. These experiments, therefore, establish a convenient in vitro model system that allows study of the regulatory influences of hapten-reactive T lymphocytes on tumor-specific, cell-mediated immune responses, and open obvious new avenues for the potential immunotherapy of growing tumors." @default.
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- W4313305953 date "1979-06-01" @default.
- W4313305953 modified "2023-10-17" @default.
- W4313305953 title "Manipulation of Cytotoxic T Lymphocyte Responses to Syngeneic Tumors" @default.
- W4313305953 doi "https://doi.org/10.4049/jimmunol.122.6.2484" @default.
- W4313305953 hasPublicationYear "1979" @default.
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