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• W4313305956 startingPage "6955" @default.
• W4313305956 abstract "Abstract Protection against intracellular bacteria by T cells is regulated by Ag-presenting molecules, which comprise classical MHC class I molecules, MHC class II molecules, and nonclassical MHC class Ib molecules. The role of CD1 molecules, which are structurally similar to classical MHC class I gene products, but less polymorphic, is not understood so far. We show that CD1 surface expression increased on APC in Listeria-infected mice. The in vivo treatment with anti-CD1 mAb reduced TGF-β2 levels and concomitantly increased secretion of the proinflammatory cytokine TNF, the Th1 cell promoting cytokine IL-12, and the Th1 cell cytokine IFN-γ at the onset of listerial infection. These findings point to a regulatory role of CD1-reactive cells in the immune response against listeriosis." @default.
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• W4313305956 date "1999-06-15" @default.
• W4313305956 modified "2023-10-14" @default.
• W4313305956 title "Cutting Edge: Anti-CD1 Monoclonal Antibody Treatment Reverses the Production Patterns of TGF-β2 and Th1 Cytokines and Ameliorates Listeriosis in Mice" @default.
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• W4313305956 doi "https://doi.org/10.4049/jimmunol.162.12.6955" @default.
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