Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313305999> ?p ?o ?g. }
- W4313305999 endingPage "6860" @default.
- W4313305999 startingPage "6853" @default.
- W4313305999 abstract "Abstract Lymphotoxin (LT) plays an important role in inflammation and lymphoid organ development, though the mechanisms by which it promotes these processes are poorly understood. Toward this end, the biologic activities of a recently generated recombinant murine (m) LTα preparation were evaluated. This cytokine preparation was effective at inducing cytotoxicity of WEHI target cells with 50% maximal killing observed with 1.2 ng/ml. mLTα also induced the expression of inflammatory mediators in the murine endothelial cell line bEnd.3. rmLTα induced expression of the adhesion molecules VCAM, ICAM, E-selectin, and the mucosal addressin cellular adhesion molecule, MAdCAM-1. When mLTα, human (h) LTα, and mTNF-α were compared, mLTα was the most potent inducer of MAdCAM-1. None of these cytokines induced the peripheral node addressin, PNAd. mLTα also induced expression of the chemokines RANTES, IFN-inducible protein 10 (IP-10), and monocyte chemotactic protein 1 (MCP-1). mRNA levels peaked 4 h following treatment with mLTα and declined through the 24-h treatment period. LTα also induced chemokine protein within 8 h of treatment, which increased through the 24-h treatment period. These data demonstrate that the proinflammatory effects of LTα3 may be mediated in part through the induction of adhesion molecule and chemokine expression. Further, LTα3 may promote development of lymphoid tissue through induction of chemokines and the mucosal addressin MAdCAM-1. These data confirm previous observations in transgenic and knockout mice that LTα3 in the absence of LTβ carries out unique biologic activities." @default.
- W4313305999 created "2023-01-06" @default.
- W4313305999 creator A5025526800 @default.
- W4313305999 creator A5045335116 @default.
- W4313305999 creator A5045569688 @default.
- W4313305999 creator A5051385259 @default.
- W4313305999 creator A5054325123 @default.
- W4313305999 creator A5061996831 @default.
- W4313305999 date "1998-12-15" @default.
- W4313305999 modified "2023-10-18" @default.
- W4313305999 title "Lymphotoxin α3 Induces Chemokines and Adhesion Molecules: Insight into the Role of LTα in Inflammation and Lymphoid Organ Development" @default.
- W4313305999 cites W1482618304 @default.
- W4313305999 cites W1485469970 @default.
- W4313305999 cites W1506071020 @default.
- W4313305999 cites W1558861739 @default.
- W4313305999 cites W1587142652 @default.
- W4313305999 cites W1589180924 @default.
- W4313305999 cites W1625203433 @default.
- W4313305999 cites W1645125543 @default.
- W4313305999 cites W1648482399 @default.
- W4313305999 cites W1882195644 @default.
- W4313305999 cites W1935356814 @default.
- W4313305999 cites W1963627373 @default.
- W4313305999 cites W1963639967 @default.
- W4313305999 cites W1966657425 @default.
- W4313305999 cites W1970010434 @default.
- W4313305999 cites W1971169128 @default.
- W4313305999 cites W1974005261 @default.
- W4313305999 cites W1997111007 @default.
- W4313305999 cites W2006281076 @default.
- W4313305999 cites W2012487047 @default.
- W4313305999 cites W2012839093 @default.
- W4313305999 cites W2021672885 @default.
- W4313305999 cites W2027344845 @default.
- W4313305999 cites W2028514452 @default.
- W4313305999 cites W2030333638 @default.
- W4313305999 cites W2033963584 @default.
- W4313305999 cites W2034794603 @default.
- W4313305999 cites W2041354260 @default.
- W4313305999 cites W2047719515 @default.
- W4313305999 cites W2048706422 @default.
- W4313305999 cites W2057379124 @default.
- W4313305999 cites W2076505832 @default.
- W4313305999 cites W2081099685 @default.
- W4313305999 cites W2088094253 @default.
- W4313305999 cites W2090076622 @default.
- W4313305999 cites W2092512708 @default.
- W4313305999 cites W2108743612 @default.
- W4313305999 cites W2109577352 @default.
- W4313305999 cites W2111680926 @default.
- W4313305999 cites W2114123652 @default.
- W4313305999 cites W2114673368 @default.
- W4313305999 cites W2116633290 @default.
- W4313305999 cites W2124841221 @default.
- W4313305999 cites W2133479688 @default.
- W4313305999 cites W2142678320 @default.
- W4313305999 cites W2144152742 @default.
- W4313305999 cites W2145591227 @default.
- W4313305999 cites W2151365647 @default.
- W4313305999 cites W2157265156 @default.
- W4313305999 cites W2159588837 @default.
- W4313305999 cites W2165664819 @default.
- W4313305999 cites W2342908712 @default.
- W4313305999 cites W4211128585 @default.
- W4313305999 cites W4230693812 @default.
- W4313305999 cites W4313379463 @default.
- W4313305999 doi "https://doi.org/10.4049/jimmunol.161.12.6853" @default.
- W4313305999 hasPublicationYear "1998" @default.
- W4313305999 type Work @default.
- W4313305999 citedByCount "64" @default.
- W4313305999 countsByYear W43133059992013 @default.
- W4313305999 countsByYear W43133059992014 @default.
- W4313305999 countsByYear W43133059992015 @default.
- W4313305999 countsByYear W43133059992016 @default.
- W4313305999 countsByYear W43133059992019 @default.
- W4313305999 countsByYear W43133059992021 @default.
- W4313305999 countsByYear W43133059992023 @default.
- W4313305999 crossrefType "journal-article" @default.
- W4313305999 hasAuthorship W4313305999A5025526800 @default.
- W4313305999 hasAuthorship W4313305999A5045335116 @default.
- W4313305999 hasAuthorship W4313305999A5045569688 @default.
- W4313305999 hasAuthorship W4313305999A5051385259 @default.
- W4313305999 hasAuthorship W4313305999A5054325123 @default.
- W4313305999 hasAuthorship W4313305999A5061996831 @default.
- W4313305999 hasConcept C13373296 @default.
- W4313305999 hasConcept C1491633281 @default.
- W4313305999 hasConcept C16224149 @default.
- W4313305999 hasConcept C164027704 @default.
- W4313305999 hasConcept C203014093 @default.
- W4313305999 hasConcept C2776914184 @default.
- W4313305999 hasConcept C2778690821 @default.
- W4313305999 hasConcept C4175445 @default.
- W4313305999 hasConcept C55493867 @default.
- W4313305999 hasConcept C61879462 @default.
- W4313305999 hasConcept C85789140 @default.
- W4313305999 hasConcept C86803240 @default.
- W4313305999 hasConcept C95444343 @default.
- W4313305999 hasConceptScore W4313305999C13373296 @default.