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• W4313306013 abstract "Abstract Human immediate hypersensitivity diseases represent the most common example of chronic excessive Th2-like activation in developed nations. While IL-13 shares many functional properties with IL-4, the intensity and regulation of environmental Ag-stimulated IL-13 synthesis by allergic vs nonallergic individuals remain ill defined. Here, we examine the intensity of polyclonally and Ag-stimulated IL-13 production by PBMC of 20 subjects with seasonal allergic rhinitis and 20 healthy controls. Polyclonally driven IL-13 responses did not differ significantly (Mann-Whitney U test, p = 0.68). In contrast, the median CD4-dependent IL-13 response among atopics was markedly stronger than nonatopics in Ag-stimulated primary culture (p = 0.0031) and exhibited a strong correlation with IL-5 (r = 0.76, p = 0.0009), but not IL-4 (r = 0.14, p &gt; 0.05), responses. IL-13 production was unaffected by blocking endogenous IL-4 or IL-5 activity or by addition of rIL-4 or rIL-5. In contrast, it was inhibited by low levels of rIFN-γ and strongly enhanced upon addition of neutralizing anti-IFN-γ mAb. Collectively, the data are consistent with a negative regulatory role for endogenous IFN-γ synthesis in controlling the intensity of systemic IL-13 responses evoked in both atopic and nonatopic populations following exposure to common Ags. They also suggest that the elevated levels of IL-4 and IL-5 characteristic of type 2-dominated responses in vivo are without detectable impact on the maintenance of recall Ag-stimulated IL-13 production." @default.
• W4313306013 created "2023-01-06" @default.
• W4313306013 creator A5038805449 @default.
• W4313306013 creator A5072841776 @default.
• W4313306013 creator A5087600572 @default.
• W4313306013 date "1998-12-15" @default.
• W4313306013 modified "2023-10-17" @default.
• W4313306013 title "Environmental Antigen-Induced IL-13 Responses Are Elevated Among Subjects with Allergic Rhinitis, Are Independent of IL-4, and Are Inhibited by Endogenous IFN-γ Synthesis" @default.
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• W4313306013 doi "https://doi.org/10.4049/jimmunol.161.12.7007" @default.
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