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• W4313306023 endingPage "7329" @default.
• W4313306023 startingPage "7322" @default.
• W4313306023 abstract "Abstract Monocytes and macrophages play a significant role in host’s defense system, since they produce a number of cytokines in response to microbial infections. We have studied IL-1β, IL-18, IFN-α/β, and TNF-α gene expression and protein production in human primary monocytes and GM-CSF-differentiated macrophages during influenza A and Sendai virus infections. Virus-infected monocytes released only small amounts of IL-1β or IL-18 protein, whereas 7- and 14-day-old GM-CSF-differentiated macrophages readily produced these cytokines. Constitutive expression of proIL-18 was seen in monocytes and macrophages, and the expression of it was enhanced during monocyte/macrophage differentiation. Expression of IL-18 mRNA was clearly induced only by Sendai virus, whereas both influenza A and Sendai viruses induced IL-1β mRNA expression. Since caspase-1 is known to cleave proIL-1β and proIL-18 into their mature, active forms, we analyzed the effect of a specific caspase-1 inhibitor on virus-induced IL-1β and IL-18 production. The release of IL-1β and IL-18, but not that of IFN-α/β or TNF-α, was clearly blocked by the inhibitor. Our results suggest that the cellular differentiation is a crucial factor that affects the capacity of monocytes/macrophages to produce IL-1β and IL-18 in response to virus infections. Furthermore, the virus-induced activation of caspase-1 is required for the efficient production of biologically active IL-1β and IL-18." @default.
• W4313306023 created "2023-01-06" @default.
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• W4313306023 date "1999-06-15" @default.
• W4313306023 modified "2023-10-10" @default.
• W4313306023 title "Virus Infection Activates IL-1β and IL-18 Production in Human Macrophages by a Caspase-1-Dependent Pathway" @default.
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• W4313306023 doi "https://doi.org/10.4049/jimmunol.162.12.7322" @default.
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