FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313306344> ?p ?o ?g. }

• W4313306344 endingPage "e0279548" @default.
• W4313306344 startingPage "e0279548" @default.
• W4313306344 abstract "Cyclic nucleotide-gated (CNG) cation channels are important heterotetrameric proteins in the retina, with different subunit composition in cone and rod photoreceptor cells: three CNGA3 and one CNGB3 in cones and three CNGA1 and one CNGB1 in rods. CNGA and CNGB subunits form separate subfamilies. We have analyzed the evolution of the CNG gene family in metazoans, with special focus on vertebrates by using sequence-based phylogeny and conservation of chromosomal synteny to deduce paralogons resulting from the early vertebrate whole genome duplications (WGDs). Our analyses show, unexpectedly, that the CNGA subfamily had four sister subfamilies in the ancestor of bilaterians and cnidarians that we named CNGC , CNGD , CNGE and CNGF . Of these, CNGC , CNGE and CNGF were lost in the ancestor of Olfactores while CNGD was lost in the vertebrate ancestor. The remaining CNGA and CNGB genes were expanded by a local duplication of CNGA and the subsequent chromosome duplications in the basal vertebrate WGD events. Upon some losses, this resulted in the gnathostome ancestor having three members in the visual CNGA subfamily ( CNGA1-3 ), a single CNGA4 gene, and two members in the CNGB subfamily ( CNGB1 and CNGB3 ). The nature of chromosomal rearrangements in the vertebrate CNGA paralogon was resolved by including the genomes of a non-teleost actinopterygian and an elasmobranch. After the teleost-specific WGD, additional duplicates were generated and retained for CNGA1 , CNGA2 , CNGA3 and CNGB1 . Furthermore, teleosts retain a local duplicate of CNGB3 . The retention of duplicated CNG genes is explained by their subfunctionalisation and photoreceptor-specific expression. In conclusion, this study provides evidence for four previously unknown CNG subfamilies in metazoans and further evidence that the early vertebrate WGD events were instrumental in the evolution of the vertebrate visual and central nervous systems." @default.
• W4313306344 created "2023-01-06" @default.
• W4313306344 creator A5011064998 @default.
• W4313306344 creator A5017376044 @default.
• W4313306344 creator A5034479771 @default.
• W4313306344 creator A5061245649 @default.
• W4313306344 date "2022-12-30" @default.
• W4313306344 modified "2023-10-14" @default.
• W4313306344 title "Ancient multiplicity in cyclic nucleotide-gated (CNG) cation channel repertoire was reduced in the ancestor of Olfactores before re-expansion by whole genome duplications in vertebrates" @default.
• W4313306344 cites W1011627610 @default.
• W4313306344 cites W1520125945 @default.
• W4313306344 cites W1525299063 @default.
• W4313306344 cites W1804357618 @default.
• W4313306344 cites W1835134358 @default.
• W4313306344 cites W1964277253 @default.
• W4313306344 cites W1965552527 @default.
• W4313306344 cites W1967194113 @default.
• W4313306344 cites W1972383232 @default.
• W4313306344 cites W1976445111 @default.
• W4313306344 cites W1979835060 @default.
• W4313306344 cites W1987811475 @default.
• W4313306344 cites W2004561786 @default.
• W4313306344 cites W2005228725 @default.
• W4313306344 cites W2008166774 @default.
• W4313306344 cites W2012940954 @default.
• W4313306344 cites W2036884791 @default.
• W4313306344 cites W2038892197 @default.
• W4313306344 cites W2055043387 @default.
• W4313306344 cites W2056564376 @default.
• W4313306344 cites W2064912476 @default.
• W4313306344 cites W2079384285 @default.
• W4313306344 cites W2081088798 @default.
• W4313306344 cites W2095661228 @default.
• W4313306344 cites W2103839548 @default.
• W4313306344 cites W2103959783 @default.
• W4313306344 cites W2111637908 @default.
• W4313306344 cites W2111647009 @default.
• W4313306344 cites W2111865215 @default.
• W4313306344 cites W2116835232 @default.
• W4313306344 cites W2118970397 @default.
• W4313306344 cites W2124425523 @default.
• W4313306344 cites W2127322768 @default.
• W4313306344 cites W2128440410 @default.
• W4313306344 cites W2141431840 @default.
• W4313306344 cites W2141572089 @default.
• W4313306344 cites W2149645705 @default.
• W4313306344 cites W2155778681 @default.
• W4313306344 cites W2155922552 @default.
• W4313306344 cites W2156125289 @default.
• W4313306344 cites W2157701114 @default.
• W4313306344 cites W2166187656 @default.
• W4313306344 cites W2170409041 @default.
• W4313306344 cites W2170747616 @default.
• W4313306344 cites W2172247938 @default.
• W4313306344 cites W2172414236 @default.
• W4313306344 cites W2296550515 @default.
• W4313306344 cites W2337283254 @default.
• W4313306344 cites W2355837210 @default.
• W4313306344 cites W2424086837 @default.
• W4313306344 cites W2601877725 @default.
• W4313306344 cites W2601895881 @default.
• W4313306344 cites W2604308930 @default.
• W4313306344 cites W2614081736 @default.
• W4313306344 cites W2785647182 @default.
• W4313306344 cites W2807587036 @default.
• W4313306344 cites W2809507176 @default.
• W4313306344 cites W2917207851 @default.
• W4313306344 cites W2919287833 @default.
• W4313306344 cites W2944429666 @default.
• W4313306344 cites W2949203785 @default.
• W4313306344 cites W2951464304 @default.
• W4313306344 cites W2956327509 @default.
• W4313306344 cites W2989897826 @default.
• W4313306344 cites W2989923168 @default.
• W4313306344 cites W2996718607 @default.
• W4313306344 cites W3009737049 @default.
• W4313306344 cites W3134671006 @default.
• W4313306344 cites W3156458251 @default.
• W4313306344 cites W3164692211 @default.
• W4313306344 cites W3184440907 @default.
• W4313306344 cites W3188348639 @default.
• W4313306344 cites W3196744396 @default.
• W4313306344 cites W3201938005 @default.
• W4313306344 cites W4205247356 @default.
• W4313306344 cites W4210290733 @default.
• W4313306344 cites W4223590166 @default.
• W4313306344 doi "https://doi.org/10.1371/journal.pone.0279548" @default.
• W4313306344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36584110" @default.
• W4313306344 hasPublicationYear "2022" @default.
• W4313306344 type Work @default.
• W4313306344 citedByCount "0" @default.
• W4313306344 crossrefType "journal-article" @default.
• W4313306344 hasAuthorship W4313306344A5011064998 @default.
• W4313306344 hasAuthorship W4313306344A5017376044 @default.
• W4313306344 hasAuthorship W4313306344A5034479771 @default.
• W4313306344 hasAuthorship W4313306344A5061245649 @default.
• W4313306344 hasBestOaLocation W43133063441 @default.
• W4313306344 hasConcept C104317684 @default.

• next