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• W4313306657 abstract "Abstract Further breeding studies were carried out to test the polygenic model for the control of the antibody response to a synthetic polypetide antigen and to examine more closely the nature of the sex influence on the antibody response. The backcrosses of reciprocally mated F1 hybrids into both the highly responding ACI strain of inbred rats and the poorly responding F344 strain yielded offspring with low, moderate and high responses in a ratio compatible with that predicted by the polygenic model. The backcrosses having a low antibody response bred true with inbreeding and with second backcrossing, as predicted, so they apparently have only those genetic factors that lead to a low antibody response. Limited inbreeding studies with the highly responding backcrosses indicated that they also bred true. Inbreeding of moderately responding backcrosses with moderately or highly responding backcrosses gave offspring that showed the whole spectrum of antibody responses, as would be expected for control by multiple genetic factors. Pedigree analyses of the antibody responses to poly(Glu52Lys33Tyr15) in a variety of hybrids of the ACI and F344 strains were performed in order to search for unexpectedly high responses (mean of the parental responses + three standard deviations) or for minimal responses (≤50 µg of antibody/ml) in the offspring of parents that made moderate amounts of antibody. Such unexpected antibody responses were found in all of the crosses examined: F1 hybrids, F2 hybrids, F1 backcrosses, inbred F1 backcrosses, second F1 backcrosses and F2 backcrosses. These findings indicate that multiple genetic factors are involved in the control of the antibody response. Furthermore, they strongly suggest that genetic recombination has occurred in the animals with the very high or very low antibody responses. In addition to the major genes controlling the antibody response, there appears to be a sex influence which causes differences in the responses of males and females. The nature of this sex influence was investigated by comparing the distribution and magnitude of the antibody response in the offspring of reciprocal matings and in males and females of the same mating. The data suggest that there are additional genetic factors active in the female which lead to a more heterogeneous antibody response in all and to a higher response in the females of the ACI strain." @default.
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• W4313306657 date "1971-04-01" @default.
• W4313306657 modified "2023-10-09" @default.
• W4313306657 title "Genetic and Cellular Factors in the Immune Response" @default.
• W4313306657 doi "https://doi.org/10.4049/jimmunol.106.4.980" @default.
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