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- W4313306962 abstract "Summary The rabbit and guinea pig antisera specific for human γE-globulin induced erythema-wheal reactions in normal human individuals and increased permeability of monkey skin capillaries, whereas the antibodies specific for other immunoglobulins did not. The minimum dose of rabbit anti-γE-antibody to induce the skin reactions in both species was 10-6 to 10-5 µg N. The activity of the anti-γE sera was removed by absorption of the antiserum with γE-globulin. The results indicate that the skin reactions by anti-γE-antibodies are reversed type allergic reactions, and that both normal human subjects and monkeys have γE-globulin on the skin sites which are sensitized by human reaginic antibodies upon passive sensitization. A normal monkey serum and a chromatographic fraction of this serum neutralized the skin reactivity of the anti-γE serum in the monkey, indicating that monkey serum contains “γE-globulin,” which has similar antigenic structure and physicochemical properties to human γE-globulin." @default.
- W4313306962 created "2023-01-06" @default.
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- W4313306962 date "1968-03-01" @default.
- W4313306962 modified "2023-10-16" @default.
- W4313306962 title "Reversed Type Allergic Skin Reactions by Anti-γE-Globulin Antibodies in Humans and Monkeys" @default.
- W4313306962 doi "https://doi.org/10.4049/jimmunol.100.3.554" @default.
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