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- W4313306969 abstract "Summary Random-bred mice fail to produce hapten-specific antibody when immunized with dinitrophenyl (DNP)-conjugated homopolymers. The nonimmunogenicity of conjugated homopolymers appears to be independent of the degree of coupling, charge and solubility of the material. All random-bred mice produce hapten-specific antibody when immunized with DNP-copolymers, DNP-terpolymers, and chemically modified derivatives of the polypeptides. The only requirement seems to be the presence of at least three different groups in the molecule. The response to the carrier portion of the molecule seems to be independent of the response to the hapten. However, where an anti-carrier response does appear, it is depressed as compared to the response to the uncoupled polypeptide. Partial chemical modification of a DNP-homopolymer, which introduces a “third” group into the molecule, or formation of an aggregate with an immunogenic protein renders these homopolymers immunogenic in mice." @default.
- W4313306969 created "2023-01-06" @default.
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- W4313306969 date "1968-02-01" @default.
- W4313306969 modified "2023-09-27" @default.
- W4313306969 title "Antigenicity of Polypeptides (Poly-α-Amino Acids)" @default.
- W4313306969 doi "https://doi.org/10.4049/jimmunol.100.2.384" @default.
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