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- W4313306983 abstract "Summary Low-molecular weight 7 S protein with γM antigenic determinants (LMW-γM) has been identified in normal human serum and in sera obtained from patients with a variety of disease states. In particular, LMW-γM protein was detected in approximately 50% of patients with lymphoproliferative disorders who had 19 S-macroglobulinemia (HMW-γM). Several types of techniques were employed to separate and distinguish these two molecular forms of γM protein found in fresh serum. These included sucrose density ultracentrifugation, gel filtration and immuno-gel filtration. This protein could also be detected directly in serum, and its level determined by immunodiffusion in 7% agarose gels. A third type of protein with γM antigenic determinants was also detected in certain sera. This γM component, which sedimented more slowly than LMW-γM and was antigenically deficient when compared with both LMW-γM and HMW-γM or with the monomeric subunit of HMW-γM appeared to result from proteolytic cleavage of HMW-γM protein." @default.
- W4313306983 created "2023-01-06" @default.
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- W4313306983 date "1969-02-01" @default.
- W4313306983 modified "2023-09-26" @default.
- W4313306983 title "Molecular Heterogeneity of Immunoglobulin-M (γM-Globulin)" @default.
- W4313306983 doi "https://doi.org/10.4049/jimmunol.102.2.496" @default.
- W4313306983 hasPublicationYear "1969" @default.
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