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- W4313307047 abstract "Abstract Conformational alteration of antigen by antibody has been deduced from antibody-induced enhancement of the catalytic activity of bovine pancreatic ribonuclease. Further support for this conclusion is adduced from the effect of ribonuclease A antibody on the activity of ribonuclease S', which consists of two enzyme fragments. These fragments, S-peptide and S-protein, are enzymically inactive when separated and active when mixed. The molar ratio (S-peptide:S-protein) at which maximum restoration of activity occurs is reduced when S-protein is allowed to combine with ribonuclease A antiserum or with activating-antibody fractions. Antibody also changes the relative effect of ribonuclease S' on different substrates." @default.
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- W4313307047 date "1971-05-01" @default.
- W4313307047 modified "2023-10-11" @default.
- W4313307047 title "Enzyme-Activation by Antibody" @default.
- W4313307047 doi "https://doi.org/10.4049/jimmunol.106.5.1381" @default.
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