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- W4313307119 endingPage "1452" @default.
- W4313307119 startingPage "1447" @default.
- W4313307119 abstract "Abstract Experiments with the sodium and magnesium salts of ethylene diamine tetra-acetic acid (EDTA) and ethylene-glycol-diamino-ethyl-tetra-acetic acid (EGTA) demonstrated that only MgEDTA fails to inhibit amine release from rabbit platelets by soluble antigen and antibody when present in a concentration just exceeding that of ionized calcium. Thus this reaction required ionized calcium in a concentration greater than 10-8 M. Addition of 10 mM EDTA to the reaction mixture interrupted amine release after it had begun. Recalcification so as to neutralize the EDTA caused amine release to resume, suggesting that this process may have a requirement for calcium ion other than for its role in the complement sequence. Incubation of platelets with antigen and antibody in the presence of EDTA caused “sensitization” of the platelets, presumably by attachment of immune complex. Platelets “sensitized” in this fashion released amine after washing and resuspension in intact, nonchelated plasma containing no antigen or antibody. The separation of platelet injury by soluble antigen and antibody into a sensitization phase and a release phase was not reported previously." @default.
- W4313307119 created "2023-01-06" @default.
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- W4313307119 date "1971-06-01" @default.
- W4313307119 modified "2023-10-16" @default.
- W4313307119 title "Rabbit Platelet Injury by Soluble Antigen and Antibody" @default.
- W4313307119 doi "https://doi.org/10.4049/jimmunol.106.6.1447" @default.
- W4313307119 hasPublicationYear "1971" @default.
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