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- W4313307287 abstract "Abstract Mouse spleen cells releasing antibody directed against human γ globulin (HGG) were enumerated using the carbodiimide modification of the Jerne antibody plaque technique. Intraperitoneal administration of mouse secondary response anti-HGG serum 1 day after primary HGG immunization resulted in an 86% decrease in numbers of anti-HGG plaque-forming cells (PFC) determined 6 days after immunization. Human anti-globulin preparations (rheumatoid factors) given intraperitoneally caused a 37% HGG-PFC decrease. In vitro plaque inhibition and serologic studies indicated that the mouse anti-HGG serum and the antibodies released by the plaque-forming cells were directed against antigenic determinants present on native HGG, whereas the rheumatoid factor preparations were directed against antigens characteristic of aggregated HGG. Thus HGG-PFC suppression by intraperitoneal rheumatoid factor may not be immunologically specific at the level of antigenic determinants." @default.
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- W4313307287 date "1971-03-01" @default.
- W4313307287 modified "2023-10-16" @default.
- W4313307287 title "Antibody Plaque-Forming Cells in Mice Immunized with Human γ Globulin (HGG)" @default.
- W4313307287 doi "https://doi.org/10.4049/jimmunol.106.3.793" @default.
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