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- W4313307340 startingPage "711" @default.
- W4313307340 abstract "Summary The rates of catabolism of human γG immunoglobulins of subclasses γG1, γG2, γG3 and γG4 were studied in heterologous species by determining the rates of elimination from the circulation of pairs of 131I- and 125I-labeled human γG myeloma proteins in mice, rabbits, guinea pigs and squirrel monkeys. In all species studied, γG1, γG2 and γG4 myeloma proteins were on the average catabolized at similar rates, whereas γG3 myeloma proteins were catabolized more rapidly. In contrast, individual myeloma proteins within a given subclass differed significantly in their catabolic rates in mice and monkeys, but except for γG3 myeloma proteins, did not differ in rabbits and guinea pigs. Also, individual myeloma proteins were catabolized differently depending on the species injected, in that certain myeloma proteins had a relatively long half-life in one species but a short half-life in another. These experiments indicate that the homologous species and heterologous species catabolize γG immunoglobulins of different heavy chain subclasses in grossly similar fashion, but that minor structural differences between individual proteins which might modulate the rate of catabolism are only recognized by certain heterologous species and not by others." @default.
- W4313307340 created "2023-01-06" @default.
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- W4313307340 date "1968-10-01" @default.
- W4313307340 modified "2023-10-02" @default.
- W4313307340 title "Catabolism of Human γG Immunoglobulins of Different Heavy Chain Subclasses" @default.
- W4313307340 doi "https://doi.org/10.4049/jimmunol.101.4.711" @default.
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