Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313307422> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4313307422 endingPage "422" @default.
- W4313307422 startingPage "413" @default.
- W4313307422 abstract "Abstract Upon activation of the complement system in guinea pig serum by endotoxin, a factor chemotactic for polymorphonuclear leukocytes is generated. This chemotactic factor has an approximate molecular weight (M.W.) of 15,000 and is independent of three minor chemotactic factors (M.W. τ;150,000, ∼68,000 and <4000) present in normal, heat-inactivated or EDTA-treated guinea pig serum. Purified, radiolabeled guinea pig C′3 and C′5 were used to determine whether the 15,000 M.W. chemotactic factor generated in serum was derived from either of these components. Endotoxin was incubated with guinea pig serum to which had been added either 125I C′3 or 125I C′5. Gel filtration elution profiles of the reaction mixtures revealed that both C′3 and C′5 were cleaved in endotoxin-treated serum. Moreover, the 15,000 M.W. chemotactic factor was identified with a cleavage product of C′5 but not of C′3. In addition, rabbit anti-guinea pig C′5, but not anti-C′3, significantly inhibited the activity of the 15,000 M. W. chemotactic factor. We conclude that the majority of chemotactic activity found in whole guinea pig serum after interaction with endotoxin is a product cleaved from C′5." @default.
- W4313307422 created "2023-01-06" @default.
- W4313307422 creator A5013120969 @default.
- W4313307422 creator A5020405246 @default.
- W4313307422 creator A5028261334 @default.
- W4313307422 creator A5051951700 @default.
- W4313307422 creator A5059064215 @default.
- W4313307422 date "1969-09-01" @default.
- W4313307422 modified "2023-10-09" @default.
- W4313307422 title "A Neutrophil Chemotactic Factor Derived from C′5 upon Interaction of Guinea Pig Serum with Endotoxin" @default.
- W4313307422 doi "https://doi.org/10.4049/jimmunol.103.3.413" @default.
- W4313307422 hasPublicationYear "1969" @default.
- W4313307422 type Work @default.
- W4313307422 citedByCount "58" @default.
- W4313307422 crossrefType "journal-article" @default.
- W4313307422 hasAuthorship W4313307422A5013120969 @default.
- W4313307422 hasAuthorship W4313307422A5020405246 @default.
- W4313307422 hasAuthorship W4313307422A5028261334 @default.
- W4313307422 hasAuthorship W4313307422A5051951700 @default.
- W4313307422 hasAuthorship W4313307422A5059064215 @default.
- W4313307422 hasBestOaLocation W43133074221 @default.
- W4313307422 hasConcept C134018914 @default.
- W4313307422 hasConcept C151730666 @default.
- W4313307422 hasConcept C153911025 @default.
- W4313307422 hasConcept C170493617 @default.
- W4313307422 hasConcept C175156509 @default.
- W4313307422 hasConcept C181199279 @default.
- W4313307422 hasConcept C185592680 @default.
- W4313307422 hasConcept C193363816 @default.
- W4313307422 hasConcept C2778815084 @default.
- W4313307422 hasConcept C43369102 @default.
- W4313307422 hasConcept C54166955 @default.
- W4313307422 hasConcept C55493867 @default.
- W4313307422 hasConcept C86803240 @default.
- W4313307422 hasConceptScore W4313307422C134018914 @default.
- W4313307422 hasConceptScore W4313307422C151730666 @default.
- W4313307422 hasConceptScore W4313307422C153911025 @default.
- W4313307422 hasConceptScore W4313307422C170493617 @default.
- W4313307422 hasConceptScore W4313307422C175156509 @default.
- W4313307422 hasConceptScore W4313307422C181199279 @default.
- W4313307422 hasConceptScore W4313307422C185592680 @default.
- W4313307422 hasConceptScore W4313307422C193363816 @default.
- W4313307422 hasConceptScore W4313307422C2778815084 @default.
- W4313307422 hasConceptScore W4313307422C43369102 @default.
- W4313307422 hasConceptScore W4313307422C54166955 @default.
- W4313307422 hasConceptScore W4313307422C55493867 @default.
- W4313307422 hasConceptScore W4313307422C86803240 @default.
- W4313307422 hasIssue "3" @default.
- W4313307422 hasLocation W43133074221 @default.
- W4313307422 hasOpenAccess W4313307422 @default.
- W4313307422 hasPrimaryLocation W43133074221 @default.
- W4313307422 hasRelatedWork W1135436615 @default.
- W4313307422 hasRelatedWork W1596865785 @default.
- W4313307422 hasRelatedWork W1993973863 @default.
- W4313307422 hasRelatedWork W2015038634 @default.
- W4313307422 hasRelatedWork W2085357479 @default.
- W4313307422 hasRelatedWork W2147110523 @default.
- W4313307422 hasRelatedWork W2313472050 @default.
- W4313307422 hasRelatedWork W2388783242 @default.
- W4313307422 hasRelatedWork W2417007386 @default.
- W4313307422 hasRelatedWork W2975251372 @default.
- W4313307422 hasVolume "103" @default.
- W4313307422 isParatext "false" @default.
- W4313307422 isRetracted "false" @default.
- W4313307422 workType "article" @default.