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- W4313307798 startingPage "1511" @default.
- W4313307798 abstract "Summary Inhibition of rabbit antibovine thyroglobulin-bovine thyroglobulin interaction was examined by immunodiffusion and quantitative precipitin techniques with compounds structurally related to thyroxine. In addition, a sensitive electrophoretic technique has been described for studying inhibition of antithyroglobulin by compounds with serologic similarity to thyroxine. In this method equilibration of antisera with small amounts of the test inhibitor (100 µg or less/ml), prior to the addition of radiothyroxine, prevented or reduced the binding of radioactivity at the γ globulin region as seen in the paper electrophoretogram: the extent of displacement of γ globulin-bound radioactivity in comparison to the control indicated the degree of inhibition. Thyroglobulin antibody inhibition by T4 and T2 was demonstrable by both serologic and electrophoretic techniques. Besides, in the more sensitive electrophoretic method, minor degrees of inhibition were noted with various mono- and diiodinated thyronines as well as with analogs, the only exception being 3,3′-diiodothyronine which showed a significant inhibitory activity. No inhibition was noted with l-thyronine. Diiodotyrosine was inhibitory in two of the sera tested, suggesting that it may also partially contribute to the specificity of thyroglobulin under certain circumstances. The findings suggest that the iodinated thyronines make up a portion of a determinant group in thyroglobulin and evidence is presented to show the greater importance of the iodine-substituted phenolic ring of the thyronine structure for the inhibition, as studied in active thyroglobulin immunity. The significance of these observations in relation to the occurrence of thyroglobulin and thyroxine antibodies in active and natural thyroid immunity is briefly discussed." @default.
- W4313307798 created "2023-01-06" @default.
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- W4313307798 date "1969-06-01" @default.
- W4313307798 modified "2023-10-16" @default.
- W4313307798 title "Studies on Thyroglobulin Immunity" @default.
- W4313307798 doi "https://doi.org/10.4049/jimmunol.102.6.1511" @default.
- W4313307798 hasPublicationYear "1969" @default.
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