Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313308242> ?p ?o ?g. }
- W4313308242 endingPage "1795" @default.
- W4313308242 startingPage "1789" @default.
- W4313308242 abstract "Abstract Pentoxifylline (PF) has been used in a wide variety of clinical situations; however, the molecular consequences of this drug are not well characterized. In this paper we assayed the effects of PF in two models of pre-B differentiation. In 70Z pre-B cells, transcriptional induction of rearranged Ig κ-chain gene in response to LPS was suppressed by PF, without affecting the induction of Rel family proteins. In contrast, κ induction by IFN-γ was not suppressed by PF, indicating that the drug inhibited certain activation pathways. We also found that LPS-induced activation of germline κ transcription and Vκ to Jκ recombination were inhibited by PF in the pre-B cell line 38B9. These observations suggest that PF may adversely affect B lymphopoiesis during chronic administration." @default.
- W4313308242 created "2023-01-06" @default.
- W4313308242 creator A5004451737 @default.
- W4313308242 creator A5011472628 @default.
- W4313308242 creator A5036983499 @default.
- W4313308242 creator A5086257285 @default.
- W4313308242 date "1998-02-15" @default.
- W4313308242 modified "2023-10-16" @default.
- W4313308242 title "Pentoxifylline Inhibits Ig κ Gene Transcription and Rearrangements in Pre-B Cells" @default.
- W4313308242 cites W1663227557 @default.
- W4313308242 cites W1871545670 @default.
- W4313308242 cites W1897976104 @default.
- W4313308242 cites W190377005 @default.
- W4313308242 cites W1964459498 @default.
- W4313308242 cites W1982062664 @default.
- W4313308242 cites W1982932518 @default.
- W4313308242 cites W2006111721 @default.
- W4313308242 cites W2009014327 @default.
- W4313308242 cites W2015886184 @default.
- W4313308242 cites W2016943603 @default.
- W4313308242 cites W2021253208 @default.
- W4313308242 cites W2024456541 @default.
- W4313308242 cites W2033810895 @default.
- W4313308242 cites W2035616122 @default.
- W4313308242 cites W2038589622 @default.
- W4313308242 cites W2043725635 @default.
- W4313308242 cites W2049909535 @default.
- W4313308242 cites W2053572117 @default.
- W4313308242 cites W2060780133 @default.
- W4313308242 cites W2065556428 @default.
- W4313308242 cites W2066916512 @default.
- W4313308242 cites W2079544213 @default.
- W4313308242 cites W2088094960 @default.
- W4313308242 cites W2088653018 @default.
- W4313308242 cites W2096589599 @default.
- W4313308242 cites W2132875885 @default.
- W4313308242 cites W2144047144 @default.
- W4313308242 cites W2149902181 @default.
- W4313308242 cites W2221403975 @default.
- W4313308242 cites W2231489492 @default.
- W4313308242 cites W2368902731 @default.
- W4313308242 cites W78369961 @default.
- W4313308242 doi "https://doi.org/10.4049/jimmunol.160.4.1789" @default.
- W4313308242 hasPublicationYear "1998" @default.
- W4313308242 type Work @default.
- W4313308242 citedByCount "4" @default.
- W4313308242 crossrefType "journal-article" @default.
- W4313308242 hasAuthorship W4313308242A5004451737 @default.
- W4313308242 hasAuthorship W4313308242A5011472628 @default.
- W4313308242 hasAuthorship W4313308242A5036983499 @default.
- W4313308242 hasAuthorship W4313308242A5086257285 @default.
- W4313308242 hasBestOaLocation W43133082421 @default.
- W4313308242 hasConcept C104317684 @default.
- W4313308242 hasConcept C109825262 @default.
- W4313308242 hasConcept C138885662 @default.
- W4313308242 hasConcept C153911025 @default.
- W4313308242 hasConcept C159654299 @default.
- W4313308242 hasConcept C179926584 @default.
- W4313308242 hasConcept C185592680 @default.
- W4313308242 hasConcept C2778453870 @default.
- W4313308242 hasConcept C2780404050 @default.
- W4313308242 hasConcept C41895202 @default.
- W4313308242 hasConcept C54355233 @default.
- W4313308242 hasConcept C86339819 @default.
- W4313308242 hasConcept C86803240 @default.
- W4313308242 hasConcept C95444343 @default.
- W4313308242 hasConcept C98274493 @default.
- W4313308242 hasConceptScore W4313308242C104317684 @default.
- W4313308242 hasConceptScore W4313308242C109825262 @default.
- W4313308242 hasConceptScore W4313308242C138885662 @default.
- W4313308242 hasConceptScore W4313308242C153911025 @default.
- W4313308242 hasConceptScore W4313308242C159654299 @default.
- W4313308242 hasConceptScore W4313308242C179926584 @default.
- W4313308242 hasConceptScore W4313308242C185592680 @default.
- W4313308242 hasConceptScore W4313308242C2778453870 @default.
- W4313308242 hasConceptScore W4313308242C2780404050 @default.
- W4313308242 hasConceptScore W4313308242C41895202 @default.
- W4313308242 hasConceptScore W4313308242C54355233 @default.
- W4313308242 hasConceptScore W4313308242C86339819 @default.
- W4313308242 hasConceptScore W4313308242C86803240 @default.
- W4313308242 hasConceptScore W4313308242C95444343 @default.
- W4313308242 hasConceptScore W4313308242C98274493 @default.
- W4313308242 hasIssue "4" @default.
- W4313308242 hasLocation W43133082421 @default.
- W4313308242 hasOpenAccess W4313308242 @default.
- W4313308242 hasPrimaryLocation W43133082421 @default.
- W4313308242 hasRelatedWork W1910053167 @default.
- W4313308242 hasRelatedWork W1998119898 @default.
- W4313308242 hasRelatedWork W2038647408 @default.
- W4313308242 hasRelatedWork W2076626517 @default.
- W4313308242 hasRelatedWork W2547794367 @default.
- W4313308242 hasRelatedWork W2566557708 @default.
- W4313308242 hasRelatedWork W2916948412 @default.
- W4313308242 hasRelatedWork W4234606113 @default.
- W4313308242 hasRelatedWork W4313308242 @default.
- W4313308242 hasRelatedWork W1896726944 @default.
- W4313308242 hasVolume "160" @default.
- W4313308242 isParatext "false" @default.