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• W4313308301 endingPage "1716" @default.
• W4313308301 startingPage "1708" @default.
• W4313308301 abstract "Abstract The development of Th1- or Th2-type responses determines the type of immune response that is elicited in response to Ag. Responsiveness to IL-12 is critical for the development of Th1-type CD4+ T cells required for cell-mediated immune responses. Addition of IL-12 to primary cultures of CD4+ T cells stimulated with OVA and splenocytes or dendritic cells resulted in the development of a Th1 phenotype with the capacity to secrete high levels of IFN-γ upon restimulation with splenic APC. The present study shows that using dendritic cells to present Ag upon restimulation reveals a requirement for additional cofactors, including IL-1α and TNF-α, which were provided by spleen cells but not dendritic cells. Furthermore, these cofactors are required for optimal IL-12-induced Th1 development in BALB/c but not C57BL/6 mice. This differential requirement for such cofactors in IL-12-driven Th1 development may play a role in genetic predisposition to Th1 or Th2 responses to infectious agents." @default.
• W4313308301 created "2023-01-06" @default.
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• W4313308301 date "1998-02-15" @default.
• W4313308301 modified "2023-10-17" @default.
• W4313308301 title "IL-1α and TNF-α Are Required for IL-12-Induced Development of Th1 Cells Producing High Levels of IFN-γ in BALB/c But Not C57BL/6 Mice" @default.
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• W4313308301 doi "https://doi.org/10.4049/jimmunol.160.4.1708" @default.
• W4313308301 hasPublicationYear "1998" @default.
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