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- W4313309119 startingPage "1726" @default.
- W4313309119 abstract "Abstract In the present study, conditions are described for the selective detection of specific 125I-(T, G)-A--L binding to peripheral B and T cells. The following observations were made: 1) B cells appear to have at least 5 times more antigen receptors than do T cells. 2) When cells were allowed to react with antigen at 37°C instead of at 4°C, this had no influence on the frequency of B-ABC. In contrast, the number of T-ABC was increased 2- to 3-fold. This increase could be prevented by sodium azide, suggesting that the exposure of antigen-binding receptors on the surface of T cells depends on cellular metabolic activity. 3) Inhibition studies with chemical analogs of (T, G)-A--L revealed a different specificity of B and T cells. Whereas excess unlabeled (T, G)-A--L, (Phe, G)-A--L and (H, G)-A--L could each block 125I-(T, G)-A--L binding to B cells, only unlabeled (T, G)-A--L could inhibit specific T-ABC. Altogether, these observations provide further evidence for profound differences between B and T cell antigen receptors." @default.
- W4313309119 created "2023-01-06" @default.
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- W4313309119 date "1974-05-01" @default.
- W4313309119 modified "2023-10-17" @default.
- W4313309119 title "Antigen Binding T and B Lymphocytes" @default.
- W4313309119 doi "https://doi.org/10.4049/jimmunol.112.5.1726" @default.
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