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- W4313309877 abstract "Abstract An attempt was made to assess the role of macrophages in resistance of irradiated mice to parental-strain and allogeneic bone marrow grafts. 1.25 to 5 mg of silica particles injected i.v. (5 µ average size) are specifically toxic to macrophages and resulted in prompt abrogation or reduction of hybrid and allogeneic resistance. The silica was equally effective when given within 2 days before or after transplantation of bone marrow cells. The effectiveness decreased with increasing intervals, but foreign marrow cells could be rescued from rejection as long as 3 days after grafting. The macrophage stabilizer poly-2-vinylpyridine N-oxide injected subcutaneously (150 mg/kg) 1 day before silica entirely prevented the suppression of hybrid resistance. It was concluded that macrophages, or a subpopulation thereof, could be the effectors of hemopoietic graft rejection by irradiated mice. The immunogenetic specificity of these allograft reactions and the suppressive effects of anti-lymphocyte agents suggest, however, that also lymphoid cells participate in this process." @default.
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- W4313309877 date "1974-09-01" @default.
- W4313309877 modified "2023-10-06" @default.
- W4313309877 title "Abrogation of Resistance to Bone Marrow Grafts by Silica Particles" @default.
- W4313309877 doi "https://doi.org/10.4049/jimmunol.113.3.798" @default.
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