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- W4313309920 abstract "Abstract Lymphocytic choriomeningitis virus (LCMV), like many viruses, induces a profound activation and expansion of CD8+ T cells. In contrast, CD4+ T cells do not increase in total number during the acute infection. We show here that mice infected with LCMV have a low but detectable frequency (<1/300) of CD4+ T cells, as detected by IL-2 production in limiting dilution assays, to each of two class II peptides during the peak of the acute LCMV response and into long-term memory. However, during the peak of the acute CD4+ T cell response, >20% of the CD4+ T cells secreted IFN-γ after stimulation with PMA and ionomycin, and >10% of the CD4+ T cells secreted IFN-γ after stimulation with the LCMV peptides. Thus, these new sensitive assays reveal a heretofore unappreciated, yet profound Ag-specific CD4+ T cell response during viral infections." @default.
- W4313309920 created "2023-01-06" @default.
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- W4313309920 date "1998-10-01" @default.
- W4313309920 modified "2023-10-17" @default.
- W4313309920 title "Cutting Edge: Detection of a High Frequency of Virus-Specific CD4+ T Cells During Acute Infection with Lymphocytic Choriomeningitis Virus" @default.
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- W4313309920 doi "https://doi.org/10.4049/jimmunol.161.7.3215" @default.
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