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- W4313309960 abstract "Abstract The present study describes abnormalities that occur in the lymph node, spleen, thymus, and blood lymphocytes of two distinct types of leukemic AKR/J mice. These two types, designated A and B leukemia, occur in a ratio of 3:1 in mice aged 7 to 10 months. Type A leukemic mice are characterized by the presence of a thymoma and enlarged peripheral lymphoid organs, and lymphocytes which 1) fail to migrate to lymph nodes, 2) exhibit normal transformation in response to PHA, and 3) have elevated sensitivity to anti-theta (θ) serum. Type B leukemic mice have an atrophic thymus and elarged peripheral lymphoid organs; their lymphocytes 1) fail to home to lymph nodes, 2) exhibit decreased transformation in response to PHA, and 3) have decreased sensitivity to anti-θ serum. The significance of the dissociation of thymus-dependent characteristics, e.g., lymphocyte recirculation, response to PHA, and expression of the θ antigen, observed in type A leukemic lymphocytes, as well as the possible origins of type A and B leukemic lymphocyte populations, are discussed." @default.
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- W4313309960 date "1973-11-01" @default.
- W4313309960 modified "2023-09-25" @default.
- W4313309960 title "Lymphocyte Populations of AKR/J Mice" @default.
- W4313309960 doi "https://doi.org/10.4049/jimmunol.111.5.1519" @default.
- W4313309960 hasPublicationYear "1973" @default.
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