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• W4313310005 endingPage "3407" @default.
• W4313310005 startingPage "3400" @default.
• W4313310005 abstract "Abstract IL-18 is a product of macrophages and with IL-12 strikingly induces IFN-γ production from T, B, and NK cells. Furthermore, IL-18 and IL-12 synergize for IFN-γ production from Th1 cells, although this combination fails to affect Th2 cells. In this study, we show that IL-12 and IL-18 promptly and synergistically induce T and B cells to develop into IFN-γ-producing cells without engaging their Ag receptors. We also studied the mechanism underlying differences in IL-18 responsiveness between Th1 and Th2 cells. Pretreatment of T or B cells with IL-12 rendered them responsive to IL-18, which induces cell proliferation and IFN-γ production. These IL-12-stimulated cells had both high and low affinity IL-18R and an increased IL-18R mRNA expression. In particular, IL-12-stimulated T cells strongly and continuously expressed IL-18R mRNA. However, when T cells developed into Th1 cells after stimulation with anti-CD3 and IL-12, they lowered this IL-12-induced-IL-18R mRNA expression. Then, such T cells showed a dominant response to anti-CD3 by IFN-γ production when they were subsequently stimulated with anti-CD3 and IL-18. In contrast, Th2 cells did not express IL-18R mRNA and failed to produce IFN-γ in response to anti-CD3 and IL-18, although they produced a substantial amount of IFN-γ in response to anti-CD3 and IL-12. However, when Th1 and Th2 cells were stimulated with anti-CD3, IL-12, and IL-18, only the Th1 cells markedly augmented IFN-γ production in response to IL-18, suggesting that IL-18 responsiveness between Th1 and Th2 cells resulted from their differential expression of IL-18R." @default.
• W4313310005 created "2023-01-06" @default.
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• W4313310005 date "1998-10-01" @default.
• W4313310005 modified "2023-10-18" @default.
• W4313310005 title "IL-12 Up-Regulates IL-18 Receptor Expression on T Cells, Th1 Cells, and B Cells: Synergism with IL-18 for IFN-γ Production" @default.
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• W4313310005 doi "https://doi.org/10.4049/jimmunol.161.7.3400" @default.
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