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- W4313310101 startingPage "967" @default.
- W4313310101 abstract "Abstract The cellular site of action of SIRS, a soluble immune response suppressor released by Con A-activated spleen cells which suppresses antibody responses to heterologous erythrocytes by murine spleen cells in vitro, was investigated. Exposure of spleen cells to SIRS for 2 hr at 37°C or 1 hr at 4°C was sufficient to suppress 5-day antibody responses in vitro. Similar exposure of splenic or peritoneal exudate macrophages to SIRS also suppressed antibody responses by untreated splenic lymphoid cells; exposure of splenic lymphoid cells to SIRS was without effect. SIRS did not act via T cells which might have contaminated the macrophage preparations. SIRS-mediated suppression could be partially overcome by an excess of normal peritoneal exudate macrophages, but not by an excess of T or B cells. These data indicate that the target cell of SIRS activity is the macrophage. The results are discussed in the context of macrophage functions that could be affected by SIRS." @default.
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- W4313310101 date "1976-09-01" @default.
- W4313310101 modified "2023-10-14" @default.
- W4313310101 title "Site of Action of a Soluble Immune Response Suppressor (SIRS) Produced by Concanavalin A-Activated Spleen Cells" @default.
- W4313310101 doi "https://doi.org/10.4049/jimmunol.117.3.967" @default.
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