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- W4313310129 abstract "Abstract During the in vitro development of cytotoxic lymphocytes (CL), suppressor cells also develop. Spleen cells or lymph node cells harvested from mixed lymphocyte cultures (MLC) on day 2 (day-2 MLC) and added to a fresh MLC suppressed the development of CL. This suppressive effect was sensitive to treatment with anti-θ and C. The suppressive effect of day-2 MLC was not due to cytotoxic effects nor to altered kinetics of the development of CL. Thymidine hot pulse experiments showed that cell proliferation is necessary for the development of both suppressor cells and CL. Although CL develop from hydrocortisone-treated spleen cells, day-2 MLC of hydrocortisone-treated spleen cells did not suppress the development of CL. These studies suggest that suppressor cells and CL are derived from different T cell subpopulations." @default.
- W4313310129 created "2023-01-06" @default.
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- W4313310129 date "1976-04-01" @default.
- W4313310129 modified "2023-10-05" @default.
- W4313310129 title "Cell-Mediated Immune Response in Vitro" @default.
- W4313310129 doi "https://doi.org/10.4049/jimmunol.116.4.1115" @default.
- W4313310129 hasPublicationYear "1976" @default.
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