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- W4313310143 abstract "Abstract Fluids from Listeria monocytogenes cultures contain products that possess a number of biologic activities. The fluids contain a mitogenic substance for B lymphocytes. Thus, their injection into mice produces striking hyperplasia of the B cell zones of the spleen. Also, lymphocytes in vitro are stimulated to proliferate, regardless of whether they are first depleted of T lymphocytes by exposure to anti-θ serum plus complement. These fluids injected intraperitoneally activate macrophages as judged by morphologic criteria. Mice that receive the products develop a transitory state of nonspecific resistance to infection by live Listeria. The relationships between B cell mitogenicity and macrophage activation—and protection—were not established. This kind of reaction of lymphoid cells to Listeria products may represent an early nonspecific line of defense against bacterial invasion." @default.
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- W4313310143 date "1974-09-01" @default.
- W4313310143 modified "2023-09-24" @default.
- W4313310143 title "Effects of Bacterial Products on Lymphocytes and Macrophages: Their Possible Role in Natural Resistance to Listeria Infection in Mice" @default.
- W4313310143 doi "https://doi.org/10.4049/jimmunol.113.3.984" @default.
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