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- W4313310160 abstract "Abstract Cultured cells from mouse thoracic duct, spleen, lymph node, Peyer's patches, and bone marrow gave rise to cells containing large amounts of cytoplasmic IgM, IgG1, and IgG2 when stimulated by bacterial lipopolysaccharide (LPS). Differentiation of IgA producers occurred in bone marrow only, and to a lesser extent than other classes. Significant IgM responses preceded development of cells containing other classes. The differentiation of IgG and IgA producers did not appear to depend on T cells, since cultures from nu/nu or thymectomized-irradiated, bone marrow-protected mice responded as well as normals. Cultures from mice rendered deficient in B cells by anti-µ treatment responded normally to T cell mitogens, but did not proliferate or give rise to immunoglobulin-secreting cells when stimulated with LPS. Bone marrow cultures gave relatively meager proliferative responses to LPS, but generated as many or more immunoglobulin-secreting cells as did other tissues." @default.
- W4313310160 created "2023-01-06" @default.
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- W4313310160 date "1975-09-01" @default.
- W4313310160 modified "2023-10-10" @default.
- W4313310160 title "B Lymphocyte Differentiation Induced by Lipopolysaccharide" @default.
- W4313310160 doi "https://doi.org/10.4049/jimmunol.115.3.671" @default.
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