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- W4313310188 abstract "Abstract Normal adult A strain mice are resistant to MHV3 infection. A strain mice immunosuppressed by 600 rads of x-irradiation or by anti-lymphocyte serum treatment became susceptible to the virus and died with specific lesions of the liver and high virus titers. However, mice immunized with MHV3 before sublethal x-irradiation resisted a second injection of virus. Resistant adult (A × C3H) F1 hybrids undergoing graft-vs-host (GVH) reaction became highly susceptible to MHV3 injected 8 days after parental cell injection. Virus titer 3 days after injection was 2 logs higher in mice undergoing GVH than in controls. However F1 hybrid mice resisted virus challenge when the first injection of virus was given 2 weeks before GVH induction. In addition, thymectomy also modified the behavior of resistant animals toward virus infection. It appears, therefore, that cell-mediated immune functions play an important role in resistance of mice to MHV3." @default.
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- W4313310188 date "1975-01-01" @default.
- W4313310188 modified "2023-10-14" @default.
- W4313310188 title "Immunopathology of Mouse Hepatitis Virus Type 3 Infection" @default.
- W4313310188 doi "https://doi.org/10.4049/jimmunol.114.1_part_1.226" @default.
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